Altered Blood Metabolome in Hereditary Angioedema Patients

Activity: Talk or presentation types › Oral presentation

Description

Hereditary angioedema (HAE) is a rare, life-threatening, inborn immunity error caused by a deficient or dysfunctional C1 esterase inhibitor (C1-INH), leading to the overproduction of bradykinin and the development of recurrent subcutaneous or submucosal edema. Although biomarkers have been discovered in many pathologies, only a few are currently used in clinical practice to diagnose HAE. Investigating the metabolomic profile of HAE, which remains unclear, may contribute to a better understanding of the pathogenesis of HAE and may explore potential new metabolic biomarkers for diagnosis, assessment of disease activity, and management of these clinical entities. This study aims to explore the metabolomic profiles of HAE patients and identify new biomarkers that could be used for diagnosing HAE and evaluating disease activity.. Blood plasma samples from 10 HAE (types I/II) patients and 20 healthy controls were measured using targeted metabolomics workflow. Metabolite analysis was performed using HILIC-based separation combined with high-resolution mass spectrometry detection. Obtained data were processed using TraceFinder 5.1 software, and statistical analysis was carried out using GraphPad Prism 9.. The quantitative values for 33 metabolites were obtained, out of which 7 metabolites had significantly lower (p
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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