Blood Purification Using the AN69ST (oXiris®) Hemofilter as a Treatment Modality for Critically Ill Septic Patient: Overview of Clinical Experience in Pauls Stradins Clinical University Hospital in Riga, Latvia

Activity: Talk or presentation types › Oral presentation

Description

data available so far has shown a hemodynamic stabilisation and improved lactate clearance for a new high-adsorption membrane oXiris® filter. However, the evidence-based use of oXiris® for sepsis is still limited. This study aims to explore the clinical effect of hemadsorption with oXiris® filter in septic shock patients.. 35 adult septic shock patients treated with at least one oXiris® set during 2022 were retrospectively analyzed. Those with known chronic kidney failure were excluded. The demographic, clinical, laboratory and survival data were collected from patient’s files. . the median age was 65 [IQR 47-73] years. Twenty-one (60%) patients had at least one comorbidity upon hospitalization, predominated by cardiovascular disease in 13 (37%) patients and diabetes in 11 (31%) patients. The median pre-treatment Sequential Organ Failure Assessment (SOFA) Score points were 12 [IQR 10– 33]. High vasoactive drug dose (median 0.27μg/kg/min [IQR 0.13–0.39] and high inflammatory markers (Procalcitonin (PCT); median 26 ng/ml [IQR 11-71] were main indications for initiation of hemadsorption. Abdominal infection [n = 13] was the most common source of sepsis. Gram-negative sepsis was found in 25 (71.4 %) patients. The median oXiris® hemofilter initiation treatment time was 19h [IQR14-48]. After one oXiris® set, median vasoactive drug dose, blood lactate, PCT levels and SOFA score points decreased by 0.06µg/kg/min (25%), 0.5 mmol/l (21%), 9.7ng/ml (37.3%) and 1 point (8.3%) respectively. Twenty-eight-day mortality was 45.7% [n=16]. In logistic regression analysis only SOFA scale and oXiris® hemofilter treatment initiation time were considered as independent risk factors for 28-day mortality (p
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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