Classification of High-Grade CIN by KI-67 Status – Considerable Prognostic Factor in Personally Tailored Management

Activity: Talk or presentation types › Poster presentation

Description

High-grade cervical intraepithelial neoplasia (CIN2 and CIN3) represent a heterogeneous disease with varying cancer progression risks. In current practice, all CIN3 and the majority of CIN2 lesions are treated in order to prevent progression to cervical cancer. However, spontaneous regression of CIN2 and CIN3 naturally occurs, but if treated according current guidelines this would constitute overtreatment. Biomarker Ki-67 indicative for a cellular proliferation could provide guidance for clinical management in women with high-grade CIN.. A cross-sectional study that enrolled a total of 110 women aged 18-65 with abnormal cytology referred for colposcopy to Reference Colposcopy Centre in Riga East Clinical University Hospital in July 2016-July 2017. Histological evaluation of cervical biopsy samples taken under colposcopy control was performed to each patient and all specimens were examined for Ki67 expression through IHC technique. The cumulative score of immunohistochemical expression Ki-67 (score 0 - 3), referred to as the "immunoscore' (IS), in the corresponding cervical scrape were evaluated.. In the total group of CIN2/3 lesions(79 cases), 5 lesions were classified as IS group 0 - 2 (6.0%), 24 lesions as IS group 3 - 4 (30.4%) and 50 lesions as IS group 5 - 6 (63.6%),confirming heterogeneity within high-grade CIN lesions. Increasing Ki-67 expression was associated with increasing CIN grade(p
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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