Clinical Signs and Risk Factor Analysis of Women Patients with INOCA – Data from Latvian Cardiac SPECT Registry

Activity: Talk or presentation types › Oral presentation

Description

A large proportion of symptomatic women referred to coronary angiography (CAG) have absence of coronary artery disease (CAD). Ischemia with non-obstructive CAD (INOCA) has been associated with cardiovascular risk (CVR) factors, although the prevalence of them remains unknown. Also, the INOCA endotypes are rarely correctly diagnosed and, therefore, no tailored therapy is prescribed. The aim of the study was to find the prevalence of women patients with INOCA referred to cardiac single photon emission computed tomography (SPECT) and to define the clinical characteristics of particular patient group. . Cardiac SPECT for women patients were performed from 2018 till 2022. Criteria for diagnosis of INOCA were symptoms of myocardial ischemia, absence of obstructive CAD, objective evidence of myocardial ischemia and / or impaired microvascular function. The diagnosis of suspected INOCA was defined if 3 out of 4 diagnostic criteria were present. The patients were analysed by clinical characteristics and CVR factors.. 787 SPECT data were analyzed. True myocardial perfusion defect was detected in 140 patients (17.8%). For 120 (85.7%) of them the CAG was performed, of which 71 (59.2%) patients had non-obstructive CAD. Totally 66 women met 3 diagnostic criteria for INOCA. The mean age of them was 56.5 ± 9.4 years. 34 (51.5%) patients were overweight (BMI>25.0 kg/m2) and 12 (18.2%) were current or ex-smokers. The most common presented CVR factors were dyslipidemia in 59 (90.8%) and arterial hypertension in 33 (50.0%) patients.. Women with high CVR and clinical suspicion of INOCA should be referred for cardiac SPECT to investigate myocardial ischemia. In these patients the further invasive testing of microvascular physiology performing intravascular measurements is planned to define INOCA endotypes.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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