Comparison of Primary Clinical Manifestation of Type I Diabetes in Children with and without Previous Exposure of SARS-CoV-2 Virus

Activity: Talk or presentation types › Oral presentation

Description

Since COVID-19 pandemic, multiple research centres have pointed out an increase in incidence of type 1 diabetes (T1D). The same trend of significantly increasing number of new cases has been recognized in Latvia. In addition, observations show more severe primary manifestation than it was before pandemic. However, so far studies were based on patient division in pre-pandemic and pandemic cases. Our aim was to analyse, whether initial manifestation of T1D differs between patients with or without previous SARS-CoV-2 exposure.. In this cross-sectional study patients were included both prospectively since August 2022 and retrospectively from year 2019, using medical records. Patients were divided depending on previous COVID-19 history: research group (exposed to SARS-CoV-2 before T1D) and control group. Data about initial T1D manifestation and metabolic status were collected and analysed.. In total, 103 patients were included in this study: 50 (48.5%) in research group (57.9% boys), 53 (51.5%) in control group (53.8% boys). Median age in groups were 9.46 (6.59-12.2) and 9.16 (3.86-13.05) years accordingly. Duration of diabetes symptoms before hospitalization was identical in both groups – median 14 days. Symptoms with significantly higher prevalence among research group were nocturia, enuresis, loss of appetite, behavioural changes and mood swings (p0.05).. Comparing SARS-CoV-2 exposed and nonexposed patients, no significant difference in severity of T1D primary manifestation has been found so far. Research will be continued in order to investigate possible reasons for increasing incidence of T1D.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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