Cytokine Profile in Patients with Primary Antibody Deficiency in Response to SARS-CoV-2 Antigen

Activity: Talk or presentation types › Poster presentation

Description

An increased COVID-19 related morbidity and mortality has been reported in patients with primary antibody deficiencies. Immunization may therefore be particularly important in these patients. Specific cytokine signatures have been shown to be related to vaccine immunogenicity. Our aim was to investigate the cytokine profile that characterize the immune response to SARS-CoV-2 antigen in vitro in patients with primary antibody deficiency.. Study included 38 subjects: 31 patients with primary antibody deficiency and 7 healthy controls. We reviewed patient’s clinical records to collect demographic and clinical data. QuantiFERON tubes were used for blood collection and sample incubation with SARS-CoV-2 spike-specific antigens or negative control for further analysis of IFN-γ production using an ELISA and IL-1β, IL-4, IL-6, IL-10, IL-15, IL-17A, IL-21, TNF-α and TGF- detection using xMAP technology.. Of the 38 individuals (31.6% men; mean age 42.26, SD= 13.1), 28 patients and 7 controls had completed the vaccination regimen with a median time 164 (IQR=114) days after vaccination. Overall, we found statistically significant increase in levels of INF- γ (p
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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