Deciphering Early Transcriptional Landscape Of Hhv-7 Infection And Reactivation

Sokolovska, L. (Speaker)
Nikolayshvili, G. (Co-author)
Waghmare, T. S. (Co-author)
Prusty, B. K. (Co-author)

Activity: Talk or presentation types › Poster presentation

Description

Human herpesvirus 7 (HHV-7) belongs to the betaherpesvirus family and is one of the least studied members of the Herpesviridae family. HHV-7 reactivation has been strongly associated with post-viral chronic illnesses like ME/CFS. In the recent past, we, for the first time, showed that HHV-7 integrated into human telomere like HHV-6. However, unlike iciHHV-6, the number of genetically inherited and chromosomally integrated HHV-7 cases is rare. We have created in vitro cell culture models carrying latent and chromosomally integrated HHV-7, which can be reactivated using chemical stimuli. Our abstract will utilize this model and lytic infection models of HHV-7 to decipher the transcriptional landscape of HHV-7 infection and reactivation. We hope to show key differences between HHV-6 and HHV-7 life cycles that can help us understand HHV-7 pathology

Period	25 Mar 2025
Event title	12th International Conference on HHV-6 & 7
Event type	Conference
Location	Himeji, JapanShow on map
Degree of Recognition	International