Detection of High-Risk Coronary Plaques Using Invasive and Non-Invasive Imaging Modalities

  • Trušinskis, K. (Co-author)
  • Lapsovs, M. (Speaker)
  • Marika Kalnina (Co-author)
  • Evija Knoka (Co-author)
  • Mairita Karantajere (Co-author)
  • Laima Caunite (Co-author)
  • Sanda Jegere (Co-author)
  • Indulis Kumsars (Co-author)
  • Andrejs Erglis (Co-author)

Activity: Talk or presentation types › Oral presentation

Description

Both near-infrared spectroscopy imaging (NIRS) and non-invasive positron emission tomography/computed tomography (PET/CT) can identify active inflammation in coronary vessel plaques and help to choose the best treatment option. NIRS generated chemograms allow us to evaluate plaque lipid content, detect lipid-rich coronary plaques, and therefore determine the future prognosis. PET/CT can diagnose the active metabolism process within the coronary artery and indicate the potential inflammation in coronary plaque. Our study provides an example of comparing PET/CT with NIRS as a diagnostic tool for coronary artery disease. . Our study combined a literature review regarding [18F] FDG PET/CT and NIRS in the context of vulnerable coronary plaques and the case report series that included 4 males with early progressive atherosclerosis and stable coronary artery disease. All patients previously were on lipid-lowering therapy. After successful coronary angiography, IVUS/NIRS were performed in the target lesion vessel. The tip of the IVUS/NIRS catheter was positioned at least 10 mm distal to the target lesion. After identifying lipid-rich coronary plaque, patients were assigned to PET/CT within 2 weeks. . From the site of meta-analysis, PET/CT’s unique features make it a promising non-invasive tool to diagnose unstable coronary plaques and possibly to guide medical interventions in cardiovascular disease. In our study, NIRS imaging mean LCBI was 300.75 showing the vulnerable plaque. The patients' mean LDL-C level is 1.98 mmol/L. The average plaque burden index is 42.9%. After performing a PET/CT scan two patients showed possible inflammation in coronary plaque similar to NIRS imaging and the mean SUVmax was 3.206.. Our research demonstrates PET/CT and NIRS as different modalities for the detection of atherosclerotic process activity and disagreement in the findings between them. The correlation between PET/CT and NIRS in the detection of vulnerable plaques and TBR threshold value for exposure to plaque inflammation is a matter of further research.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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