Detection of Prostate Cancer Recurrence after Radiation Therapy – First Experience

Activity: Talk or presentation types › Poster presentation

Description

Radiation therapy is one of the standard radical treatment methods for localised prostate cancer (PCa). Around 20-30% of patients develop a biochemical and subsequently a clinical recurrence. Early detection of local recurrence facilitates additional focal treatment. Our objective is to evaluate detection of early recurrence using  MRI and MRI – Fusion guided biopsies when PSA is in the range 1.0-2.0 ng/ml over nadir.. We performed a prospective study by re-staging evaluation for patients with a PSA > 1.0 ng/ml over nadir with a multi multiparametric prostate MRI, abdominal CT, and bone scintigraphy. The patients were divided into two groups according to the PSA value: 1.0-2.0 ng/ml and > 2.0 ng/ml. Patients with a positive MRI finding (PIRADS III-V) underwent an MRI – fusion guided transperineal prostate biopsy. . The cohort of  45 patients was analysed. Mean age is 72.8 years, and PSA value from 1.01 to  21.9 ng/ml. We have 17 patients in the first group and 28 patients in the second group. In the first group MRI was positive in 14 cases (82%). The most common finding was PIRADS 5 lesions in 5 cases, PIRADS 4 in 4 cases, and other were PIRADS 3 lesions.  And the MRI-Fusion biopsy was positive in 14 out of 17 cases (82 %). 9 out of 14 (64%) cases had ISUP grade 5 or 6. In the second group all MRI results were suspicious for PCa recurrence.  The majority: 16 (57%) had PIRADS 4 or 5 lesions. The following biopsy was positive in 27 (96%) cases and 13 of them (48%) had ISUP grade 3-6. . The firs experience shows promising results for early detection of recurrent PCa after radiotherapy using MRI and MRI-Fusion guided biopsies for patients with a PSA rise 1.0-2.0 ng/ml over nadir. Further data collection is needed to stratify the results.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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