Early Recurrence after Liver Resection in Patients with Colorectal Cancer Liver Metastases

Activity: Talk or presentation types › Oral presentation

Description

Colorectal cancer is the second leading cause for cancer associated deaths worldwide, with 25 – 30% of those affected developing liver metastases. After curative surgery, 70% will develop recurrence within first two years after resection. The aim of this single center retrospective study was to determine the incidence of metastatic disease-free state one year after curative resection in association with known risk factors for recurrence.. There were 34 patients included in the study and divided into two groups regarding one year recurrence of colorectal cancer metastases after liver resection. Known risk factors of colorectal cancer liver metastases recurrence were analyzed between the two groups.. There was 47% recurrence rate one year after the liver resection. In the one year recurrence group 64.7% were male and 35.3% were female, in disease free group 52.9% were male and 47.1% were female(p=0,486). The mean age in recurrence group was 63.6±12.9 and in disease free group 61.5±10.9,(p=0.361). The mean time from first surgery till first liver metastasis was 5.6±7.5 months in recurrence group and 12.3±15.5 in disease free group(p=0.928). There were 1.8±1.3 metastases in recurrence group and 1.6±0.7 in disease free group(p=0.930), with the mean size being 29.2±14.0 mm vs 29.4±11.4 mm respectively(p=0.679). The Neu/Ly ratio was 3.6±2.5 in recurrence group vs 3.3±4.8 in disease free group(p=0.174). There were 1.2±1.0 positive lymph nodes in the initial colorectal specimen of recurrence group and 0.6±1.3 in disease free group(p=0.253). There was statistically significant difference between CEA levels a year after liver metastasis resection in recurrence group and in disease free group 21.72 vs 12.56 respectively(p=0.05).. Early recurrence remains a major issue in patients after liver resection for colorectal cancer metastases. CEA levels one year after resection were lower in disease free group. A study with a larger patient population is necessary for more relevant results.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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