Description
The acronym ESKAPE includes six nosocomial pathogens that exhibit multidrug resistance and virulence: Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter spp. The aim of the study was to analyze the incidence of ESKAPE pathogens and antimicrobial resistance (AMR) at the intensive care unit (ICU) of Liepaja Regional Hospital (LRS) in 2022.. From 22.07.2022. till 11.01.2023. were recruited 51 LRS ICU patients: male - 27, female - 24. 96 ESKAPE pathogens were identified (A.baumannii – 31/96 (32%), P.aeruginosa – 25/96 (26%), K,pneumoniae – 13/96 (14%), E.coli/E.cloacae – 11/96 (11%), S.aureus – 10/96 (10%), E.faecium – 6/96 (6%)). AMR testing were perfomed with phenotypic methods according EUCAST recommendations. Sample’s materials were bronchoalveolar lavage – 43, tracheal aspirate - 15, urine - 14, blood - 8, wound samples - 6, central line tip - 3, intraoperative abdominal sample – 3, nasal sinus puncture – 1, abdominal drenage fluid – 1, bile sample – 1, nasopharingeal swab – 1.. In this review we assessed the current state of AMR in ESKAPE pathogens. All A. baumannii samples were multidrug-resistant and carbapenem-resistant (CRAB), two of which werepandrug-resistant isolates with no effect to polymyxin-class antibiotics. P. aeruginosa displayed resistance to multiple classes of antibiotics, with 20% sample’s resistance to carbapenems. E. cloacae showed resistant to aminopenicillins and 4th generation cephalosporins. E. coli displayed resistance to aminopenicillins (50%), 3rd generation cephalosporins (20%) and fluoroquinolones (10%). There wasn’t found carbapenem-resistant K. pneumoniae (CRKP) strains. Methicillin resistance in S. aureus – 20%. Vancomycin-resistant E. faecium (VREfm) – 33%.. Most frequently isolated pathogens - A.baumannii and P.aeruginosa - showed expansive multi-drug resistance mechanisms, that, with the rise of VREfm strains, show an emerging area of concern from nosocomial infections. Findings recommend further research, including genomic testing.| Period | 27 Mar 2023 → 31 Mar 2023 |
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| Event title | RSU Research Week 2023: Research Week 2023 Rīga Stradiņš University |
| Event type | Conference |
| Organiser | Riga Stradins University |
| Location | Riga, LatviaShow on map |
| Degree of Recognition | International |