Evaluation of Drug Therapy in Polymorbid Patients with Chronic Musculoskeletal Pain

Activity: Talk or presentation types › Oral presentation

Description

Determine drug interactions in pharmacotherapy for chronic musculoskeletal pain (CMP) in combination with therapy for other chronic diseases for polymorbid patients (≥2 chronic diseases), assess the safety of therapy from from the point of view of a clinical pharmacist and develop recommendations for drug interaction prevention and risk reduction.. The study design is a retrospective study at Pauls Stradins Clinical University Hospital. Data were collected from 53 polymorbid patients (n=53) medical records. All patients received treatment for at least one CMP fit in 3 categories: chronic diffuse musculoskeletal pain, and back pain, periferal joint pain. At the same time all of them had 2 - 13 different comorbid disorders and received treatment for them. All medications were used simultaneously over a 2 week interval.. 54,7% of the pharmacotherapies were safe, but require patient monitoring. 43,4% were not safe and it is recommended to consider a therapy modification because interactions were found to be potentially dangerous. 1,9% of therapies require immediate medication change. Between the number of medications used and drug interactions, there was a strong positive correlation. The most common risks associated with drug interactions were gastrointestinal bleeding, CNS depression, decreased effect of hypertension drugs under the influence of NSAIDs, increased risk of NSAID toxicity, reduced effect of diuretics and hypoglycemic agents under the influence of opioids.. More than half of the therapies were safe, but almost half were not from the point of view of drug interactions and require a revision of the therapy. There are preventive measures aimed at early detection and prevention of possible interactions. The number of drugs used is correlated with the number of interactions, showing that polymorbid patients require a particularly detailed analysis of drug therapy.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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