Description
Objectives. With increasing incidence of type 1 diabetes (T1D) in children, it is important to detect factors that influence control of the disease to decrease the rate of complications in early life. The aim of this study was to evaluate control of T1D one year after diagnosis and to analyze influencing factors.Materials and methods. Patients aged 1 to 18 years were included prospectively from August 2022 till November 2023 at the time of initial manifestation of T1D. Factors assessed one year after diagnosis were: severity of initial manifestation, HbA1c level, time in range (TIR), frequency of diabetic ketoacidosis (DKA) and hypoglycemia, depression signs (PHQ-9 questionnaire), eating disorders (DEPS-R questionnaire), physical activity. Patients were divided in 2 groups: good metabolic control (HbA1c level <7%, group 1), unsatisfactory control (HbA1c level ≥7%, group 2).
Results. T1D control was analyzed in 86 patients (55.8% boys). In one year, 46 patients (53.5%, mean age 9.6 years (±4.4), had good diabetes control. Mean age in group 2 was 9.5 years (±4.4). Diabetes control parameters in group 1 versus group 2: median HbA1c 6.38% (6.14-6.70) versus 8.26% (7.63-9.91), mean TIR 69.4% (±15.4) versus 35.4% (±20.1), median 2 (0-8) versus 1 (0-4) symptomatic hypoglycemia per month, 1 DKA versus 7 cases (12.5% patients) with DKA per year. Depression signs were identified in 4 (23.5% from tested patients) versus 9 (75%) patients, eating disorders in 4 (8.7%) versus 3 (7.5%) patients. Patients from group 1 had significantly lower prevalence of DKA as initial manifestation: 47.8% versus 70% in group 2 (p=0.04). Patients from group 1 are significantly more often doing sports (median 5 (4-6.8), high intensity sports (median 3.5 (2-5) times per week), than group 2 (p<0.05).
Conclusions. Initial manifestation and frequency of physical activity may influence T1D control 1 year after diagnosis. More data is necessary to analyze other factors.
| Period | 24 Mar 2025 → 28 Mar 2025 |
|---|---|
| Event title | RSU Research week 2025 |
| Event type | Conference |
| Organiser | Rīga Stradiņš University |
| Location | Rīga, LatviaShow on map |
| Degree of Recognition | International |