Factors Associated with Intentional Discontinuation of Insulin Therapy in Adult Type 1 Diabetic Patients Hospitalised for Diabetic Ketoacidosis

Activity: Talk or presentation types › Poster presentation

Description

Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes mellitus (DM) and is commonly seen in patients with DM type 1 (T1DM). This acute complication of T1DM is associated with high morbidity and mortality rates. Many patients experience repeated hospitalizations due to DKA. The condition of DKA usually requires a long period of hospitalization with high treatment costs. The aim of the work is to study the factors associated with intentional discontinuation of conventional intensified insulin therapy in adult with T1DM type patients hospitalized due to DKA.. In a retrospective study, medical history data of 120 adult patients were analyzed – demographic factors, number of hospitalizations due to DKA, severity of DKA and treatment outcomes, comorbidities, late complications of DM, and possible reasons for intentional discontinuation of insulin therapy. The study took place at the Riga Eastern Clinical University Hospital and the Paula Stradiņš Clinical University Hospital in the period from January 2019 to May 2022.. The analysis of the research data shows that young, married, and employed men are most often hospitalized due to intentional discontinuation of conventional intensified insulin therapy with following development of DKA. More than a third of patients had repeated hospitalizations within one year. Most patients are diagnosed with severe DKA at the time of hospitalization. The mortality rate in the study patient population was 4.2%. The majority of patients had more than four comorbidities and at least one late complication of DM. The most common possible reasons for intentional discontinuation of insulin therapy were poor DM metabolic compensation and alcohol consumption.. Several factors are associated with intentional discontinuation of conventional intensive insulin therapy with following development of DKA in T1DM patients. Prospective clinical studies are needed to clarify the causal relationship between these factors for more effective prevention of DKA.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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