General Anaesthesia with Dexmedetomidine Is Safe and Effective in Pelvis Osteosynthesis Trauma Patients

  • Elizabete Svareniece (Speaker)
  • Ozoliņa, A. (Co-author)
  • Jelena Kobzeva (Co-author)
  • Natalja Vnukova (Co-author)
  • Jevgenijs Movcans (Co-author)

Activity: Talk or presentation types › Oral presentation

Description

Dexmedetomidine (Dex) sedative, analgetic effects might be desirable during general anaesthesia. Aim was to evaluate efficacy and safety of Dex for general anaesthesia in patients undergoing pelvis osteosynthesis.. In prospective single-blinded trial ASA II trauma patients were randomly assigned to general anaesthesia with Phentanyl (Ph-GA) or Phentanyl with Dex (Ph-DEX-GA) groups. Ph-DEX-GA received Dex 1 mcg/kg/h over 10 min after intubation, followed by infusion 0.4 mcg/kg/h until end of surgery. Mean atrial pressure (MAP), heart rate (HR) was recorded after intubation (T0), after one (T1), after two (T2) hours, after extubation (T3). Pain intensity (NRS) was analysed 0, 6, 12 and 24 h postoperatively. Primarily we assessed pain intensity after surgery and total intraoperative Phentanyl consumption. Secondary, influence on haemodynamic (MAP < 65 mm/Hg or bradycardia < 50 x/min). P < 0.05.. Preliminary 18 patients: Ph-GA (n=9), Ph-DEX-GA (n=9), mean age 51.5 ± 9.9 years were collected. Mean duration of surgery (244 ± 91 min) and anaesthesia (314 ± 99 min) in both groups were similar.Pain at rest after surgery was similar: Ph-GA vs. Ph-Dex-GA: T0 2.4 vs. 2.6, T6 2.9 vs. 3.4, T12 2.8 vs. 3.2, T24 2.6 vs. 2.9, though Phentanyl consumption during surgery was lower in Ph-DEX-GA group 0.28±0.1 mg vs. 0.7±0.2 mg. More pronounced effect to hemodynamic was observed in Dex group. Drop from baseline of MAP Ph-GA vs. Ph-Dex-GA: T1 -14.9% vs. -26.3%, T2 -16.4% vs. -29.2%, T3 -6.6% vs. -14.6%; HR Ph-GA vs. Ph-Dex-GA: T1 -12.3% vs. -19%, T2 +6.8% vs. -29.2%, T3 -5.2% vs. -22%. Treatment for intraoperative hypotension (ephedrine 5-10 mg) received 5 patients - 4 in Ph-Dex-GA and 1 in Ph-GA group.. Dex for general anaesthesia is effective and safe, by reducing Phentanyl consumption provides good pain control in pelvis osteosynthesis patients. However, it potentially leads to greater hemodynamic fluctuations.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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