Gut Microbiome Differences between Patients with Colorectal Adenomas and Healthy Individuals

Activity: Talk or presentation types › Poster presentation

Description

One of the factors in the development of colorectal cancer (CRC) is the gut microbiome. Its effect on promoting colon pathology occurs both through the microorganisms themselves and their metabolites. It is known that the most common pathway of CRC development is the adenoma-carcinoma; therefore, research is needed not only on the relationship of CRC with changes in gut microbiome composition, but also to specify whether the presence of CRC precursors - benign colon adenomatous polyps could be early associated with changes in the composition of the gut microbiome. The aim of our study was to determine whether the composition of the gut microbiome was different in individuals with colon adenomas detected during colonoscopy examination compared to individuals without adenomas.. Fecal samples were collected from 48 patients with colorectal adenoma (AD) and 74 healthy controls. Gut microbiome composition was determined using a 16S rRNA gene sequencing approach. Differential abundance testing was performed by the Linear discriminant analysis effect size (LefSe) tool.. The most pronounced bacterial discriminants of the AD group include the genus Mediterraneibacter, previously described as associated with colorectal cancer[1] , and the species Carnobacterium divergens. Healthy individuals were characterized by an increase in representatives of Alistipes, Akkermansia, Odoribacter, Lactococcus, Anaerotignum, and Coprobacter. . Significant differences in the gut microbiome composition have been detected between patients with colorectal adenomas and healthy individuals, indicating potential microbiome-related changes at the early stages of colorectal cancer development.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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