Human Leukocyte Antigen Class II Alleles in HIV-Positive Patients with Primary Skin Pathologies and in Control Group in Latvia

Activity: Talk or presentation types › Poster presentation

Description

HIV-infected patients typically exhibit unusually dry skin and may present inflammatory or eczematous eruptions like primary skin pathologies (PSP). These include atopic dermatitis, seborrheic dermatitis, psoriasis, pruritic papular eruption of HIV, eosinophilic folliculitis, papular urticaria, prurigo nodularis. At the same time HLA diversity can influence on the likelihood of manifestation of PSP in HIV-infected patients. Evaluation of innate immunity defects in these patients is possible with HLA class II allele typing.This study assessed the distribution of variants of HLA Class II alleles in patients with HIV and PSP within the Latvian population. . There were 70 patients aged 34 to 72 years in our test sample, of whom 22 (31%) were females and 48 (69%) were males. 62 patients (88%) had tuberculosis. All patients in our sample had HIV and PSP. To determine risk alleles of the HLA Class II gene, HLA-profiles of a control group of 80 adults (various age and sex, no HIV) was created. . When comparing the distribution of HLA-DRB1/DQA1/DQB1 alleles in our test and control groups it was found that the alleles HLA-DRB1*04:07,01:15, 04:12,13:17, HLA-DQA1* 0103:0501, 0101:0501, 0102:0301 and HLA-DQB1*0401-2:0401-2, 0301:0302, 0301:0401-2, 0501:0602-8 are more represented in the test group, these alleles are identified as risk alleles for manifestation of PSP in HIV patients. HLA-DRB1*07:13, 01:13, 11:13, HLA-DQA1*0101:0101, 0101:0102, 0501:0501 and HLA-DQB1*0201-2:0301, 0301:0602-8, 0301:0301 were identified as protective alleles.. Our findings indicate that the HLA class II alleles -DRB1, -DQA1 and -DQB1are associated with a trend to risk/protection relating to PSP in HIV patients. Further research is needed to determine the protective and risk alleles of HLA class II for these patients in Latvia. HLA class II allele typing can provide additional information for the prognosis of PSP in HIV patients and monitoring its treatment.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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