Interictal Correlations between Body Mass Index and Cytokines Levels in Migraine

Activity: Talk or presentation typesOral presentation

Description

The aim of the study was to clarify correlations among body mass index (BMI) and serum levels of cytokines in migraine with and without aura female patients during interictal period. 14 migraineurs with aura, and 12 – without aura during their interictal period were compared with age and BMI matched 25 controls. Interleukin-8 (IL-8), soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM1), matrix metalloproteinase-9 (MMP-9), interferon gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1), transforming growth factor alpha (TGF-α) and plasminogen activator inhibitor-1 (PAI-1) were measured in serum by ELISA method.. Migraineurs had significantly increased levels of IL-8, but decreased serum levels of PAI-1 and sICAM-1 during the interictal period, regardless of aura. BMI correlated with BP, and also with IFN-γ and MMP-9 only in patients with aura. . There were three correlations in migraine patients with aura that were absent in patients without aura: between IL-8 and PAI-1; MMP-9 and IL-8; IL-8 and sICAM-1. Migraineurs without aura, on the other hand, had correlations that patients with aura did not have (between PAI-1 and MCP-1, sICAM-1; between MMP-9 and sICAM-1, MCP-1; between TGF-α and PAI-1, MMP-9, sICAM-1; between sICAM-1 and MMP-9, PAI-1, MCP-1; as well as between sVCAM-1 and MCP-1). PAI-1, TGF and MMP-9 could be used as biomarkers to distinguish migraineurs from healthy individuals.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational