Is Multiparametric Ultrasound the Future of Unstable Carotid Plaque Diagnostics?

Activity: Talk or presentation types › Poster presentation

Description

Evaluate the effectiveness of contrast enhanced ultrasound (CEUS) for detecting carotid plaque instability and neovascularization in reference to Superb Microvascular Imaging (SMI), and histological samples.. Incidence of stroke every year increases worldwide, According to World Health Organization In 2020, 1 in 6 deaths from cardiovascular disease was due to stroke, about 87% of all strokes are ischemic strokes, in which blood flow to the brain is impaired and atherosclerotic disease is one of the main causes. In these situations, CEUS and SMI is used to detect neovascularization, as a factor of atherosclerotic plaques instability. During the prospective research, 88 patients underwent Doppler ultrasound examination, and significant hemodynamic plaques (>50%) were detected, following SMI and CEUS. The neovascularization was categorized in three categories (Grade 0, Grade 1, Grade 2) and results were compared to histological finding from endarterectomies in 62 patients.. There was a positive correlation between SMI and histological material, r=0.319; p=0.01. Also, positive correlation was found between CEUS and histological material, r=0.456; p=0.000. Moderate positive correlation was observed between CEUS and SMI r=0.669; p=0.000. However, ROC curve analysis showed that SMI is less sensitive than CEUS (51.22% vs 80.56%) Totally CEUS method is valued with the sensitivity- 80.56%, specificity- 77.75%, accuracy- 79.29% with limitation among calcified plaques. Grade 1 atherosclerotic plaques showed delayed neovascularization (mean time 32 seconds) in comparison to Grade 2 (mean time 19 seconds).. CEUS and SMI as a part of multiparametric ultrasound method shows promising results for carotid plaque instability evaluation than US doppler or microvascular imaging solely and it can be advised in clinical practice for patients with carotid artery soft plaques. Grade 2 plaques show earlier neovascularization than Grade 1 atherosclerotic plaques. However, the sensitivity of CEUS and SMI decreases in markedly calcified plaques.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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