Late-onset Multiple Sclerosis

Activity: Talk or presentation types › Poster presentation

Description

To describe the clinical and radiological characteristics of multiple sclerosis patients who were first diagnosed with multiple sclerosis after the age of 40 years and to determine the proportion of these newly diagnosed late-onset multiple sclerosis patients.. Patient data from the Multiple sclerosis unit of Riga East University Hospital was collected and medical histories of patients who were newly diagnosed with multiple sclerosis (ICD-10 G35) after the age of 40 years were enrolled from January 1st, 2019 till December 31st, 2022. Data about clinical characteristics and cerebral and spinal MRI were obtained. The SPSS 29.0 program was used for statistical data analysis.. We identified 176 newly diagnosed MS patients of which 44 (25%) had late-onset multiple sclerosis (LOMS), with a mean age of 50,4 years at the time of diagnosis. The average duration of symptoms before the time of diagnosis was 6,48 years. The LOMS group had a higher proportion of females (68,2%) and patients with relapsing-remitting disease course (84,1%). The mean EDSS score was 2,48. The most common changes in MRI findings were one to five juxtacortical (n=18, 40,9%) and infratentorial (n=27, 61,4%) lesions. 36 patients (81,82%) had spinal cord lesions – most commonly one to five lesions in cervical and thoracic parts (respectively, n=23 (52,3%) and n=25 (56,8%)). 20 patients presented with optical nerve demyelination, but atrophy was determined for 15 patients. Overall, 16 patients (36,37%) were diagnosed with varying severity types of brain or spinal cord atrophy.. LOMS patient population had a higher proportion of females and patients with relapsing-remitting disease course. 81,82% of patients had spinal cord lesions on MRI. LOMS patients accounted for 25% of the total number of newly diagnosed multiple sclerosis patients, which can be due to the fact that the symptoms of MS in these patients appeared several years before the diagnosis.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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