Lipoprotein (a) as Additional Marker for Cardiovascular Risk Assessment

  • Marija Dončaka (Speaker)
  • Marta Burlačuka (Co-author)
  • Skrode, E. (Co-author)
  • Jana Osīte (Co-author)
  • Storoženko, J. (Co-author)

Activity: Talk or presentation types › Poster presentation

Description

Lipoprotein(a) (Lp(a)) is macromolecular complex of low-density lipoprotein and protein apolipoprotein (a), which can be used as an indicator of increased risk of early atherosclerosis .Lp(a) level is genetically determined and this complex doesn’t excreted by the liver. Lp(a) level is not affected by diet or physical activity.Lp(a) alone increases the risk of CVDs by 1.2 times, byt Lp(a) and smoking – 3.6 times.High Lp(a) with high LDL-cholesterol increase risk of CVDs by 12 times, but together with elevated homocysteine - 30 times.Therefore, it would be useful to measure Lp(a) in all patients with a complicated anamnesis, even with a normal lipidogram.Aim of the research is to understand how many Lp(a) were determined annually and how many and how many of them were with and without lipidogram changes.. Analyzer: Roche, Cobas Pro (c503).Detection methods are:Lp(a) - Particle enhanced immunoturbidimetric assay. Total cholesterol – Enzymatic, colorimetric assay. LDL and HDL cholesterol: Homogeneous enzymatic colorimetric assay.. 398 Lp(a) were analyzed in period of 01.12.2021-01.12.2022.High Lp(a) level was detected in 95 (23,87%) cases.From 95 cases: 45.26% were with no changes in the lipidogram, 44,21% were with high LDL-cholesterol and total cholesterol, but in 10,53% lipidogram wasn’t determined.In 303 (76,13%) cases with normal Lp(a) level : 48,84% were with no changes in the lipidogram, 47,52% were with high LDL-cholesterol and total cholesterol, but in 3,64% lipidogram wasn’t determined.In period of 01.12.2021-01.12.2022 325342 tests of total cholesterol were analized and only in 0.12% cases Lp(a) was also determined44,38% from these tests were with total Cholesterol level < 5.0 mmol/L, Of that number, 57,750 patients might have elevated Lp(a) provisionally.. The Lp(a) test is not widely used, despite its importance. Using Lp(a) determination together with a routine lipidogram could detect patients at high risk of CVDs more quickly.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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