Metabolome as a Predictive Biomarker of Outcome of Induction of Labour

Description

Objectives. The rate of induction of labour is increasing in last decades, with its main goal to decrease the maternal and neonatal morbidity and mortality. However, it is not a risk-free childbirth intervention. Multiple biomarkers are used to predict the outcome of labour induction, but yet none of these is 100% sensitive, and researchers continue looking for new and more sensitive biomarkers like metabolome. . Materials and Methods. The implementation of project “Role of Metabolome, Biomarkers and Ultrasound Parameters in Successful Labour Induction” was started in Riga Maternity hospital in January 2021. The inclusion criteria were: healthy nulliparous women with singleton term pregnancy and cephalic presentation, with indication for labour induction, intact membranes and Bishop score 6 or less. Mass spectrometry metabolomics analysis was performed on blood samples collected from participants right before the labour induction. Labour induction was performed with combined method – Foley catheter and prostaglandin (Misoprostol) orally. . Results. There is limited number of studies about maternal metabolome during pregnancy and labour. One study showed that there was a difference in maternal metabolome in correlation to the onset of labour – spontaneous or induced. This suggests that in case of labour induction the activated pathway is different from that in spontaneous labour, and possibly could be associated with adverse pregnancy outcomes and unsuccessful labour induction. Results of our pilot study will be presented at 'RSU Research week 2023'. . Conclusions. The maternal metabolome is a potential biomarker to predict the outcome of induction of labour.
Acknowledgements:
This research is funded by the Latvian Council of Science project “Role of Metabolome, Biomarkers and Ultrasound Parameters in Successful Labour Induction”, project No. lzp-2021/1-0300.

Period	29 Mar 2023
Event title	RSU International Research Conference 2023: Knowledge for Use in Practice
Event type	Conference
Organiser	Rīga Stradiņš University
Location	Riga, LatviaShow on map
Degree of Recognition	International