Mitochondrial Genome Variation Demonstrates Associations with Coronary Artery Disease and a Plethora of Well-Established Disease Risk Factors and Dietary Preferences

Activity: Talk or presentation types › Oral presentation

Description

Coronary artery disease (CAD) is a complex disease, driven by genetic and lifestyle factors. Currently identified single-nucleotide variants (SNVs) associated with CAD explain 1%) MT-SNVs were subjected to association analyses with CAD, as well as 109 additional traits, including 24 well-established risk factors (age, hypertension, high cholesterol levels, smoking) and 85 dietary preferences from food frequency questionnaires. . We identified 3 study-wide significant (PT (ND3), m.14783T>C and m.15043G>A (CYB). m.10400C>T and m.14783T>C were also found more frequently in individuals displaying high triglycerides and less frequently in those being physically active. The same MT-SNVs were associations with several dietary habits related to alcohol (any type from red wine to spirits), coffee/tee, water, sugar, egg and dairy consumption, the daily amount of fruit (fresh/dried) and vegetables (raw/cooked), as well as preferences related to type/amount of milk (full cream vs. skimmed), spread (flora/benecol vs. butter/margarine), cereal (muesli vs other) and bread (wholemeal vs. other). . Overall, our results suggest that MT-SNVs demonstrate associations with CAD and a plethora of well-established disease risk factors and dietary preferences. Further studies are needed to conclusively determine the role of MT-SNVs in modulating susceptibility to CAD.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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