Modelling of 3D Printer Emissions Deposition in Human Respiratory Tract and Potential Inflammatory Processes

Description

Particulate matter(PM) is one of the main elements of air pollution. PM can be divided based on its diameter size into: coarse≤10 microns(PM10 ), fine≤2.5 microns(PM2.5) and ultrafine≤0.1 microns(PM0.1) ,consequently, will have different deposition capacity in the human respiratory tract(HRT). This research aims to determine the deposition fraction(DF) of PM emitted during the 3Dprinting process in different regions of the HRT based on mass concentration(MC) and geometric mean diameter(GMD).Also, do the systematic review based on deposition modeling regarding inflammatory processes and as consequence possible pathologies.. The research was carried out within a project of National Programme Grants(RSU Grants) “Occupational health and safety risks during 3D printing”6-ZD-22/22/2022. We studied PM deposition in HRT-entire, generation-specific; upper/lower, lobar and central/peripheral lung tissues using the Multiple Path Particle Dosimetry Model(MPPD-V3.04). . The biggest DF in entire HRT is PM10(0.9566) and the smallest PM2.5(0.2089). The biggest DF in lower respiratory tract(LRT) is PM0.1(0.4868), the smaller DF is PM10(0.1853) and the smallest DF is PM2.5(0.1225). PM0.1 deposits mainly in lungs(56%), PM2.5 mostly deposits in the upper respiratory tract(URT)(41%) and lungs(39%), but PM10 mostly deposits in the URT(81%). The biggest DF in lung for all PM-lower lobes(range: PM2.560-PM1061%), smallest-right middle lobe. DF of all PM starts to progress on the level of respiratory bronchioles and reaches its maximum at alveolar sacs. All PM DF is bigger in peripheral lung region(range: PM1069-PM0.171%).. The biggest DF in HRT as a whole is coarse(PM10), but in the LRT ultrafine(PM0.1). All of the PM are depositing mostly on the level of alveolar sacs, lower lobes and peripheral tissue of the lungs. PM decreasing in diameter, tend to deposit mostly in the deeper levels of HRT, therefore catalysing inflammatory processes, which could lead to the chronic inflammation and damage of the different organ systems.

Period	29 Mar 2023
Event title	RSU Research week 2023: Society. Health. Welfare
Event type	Conference
Conference number	9
Organiser	Rīga Stradiņš University
Location	Riga, LatviaShow on map
Degree of Recognition	International