Modern Therapy Possibilities for Severe Metabolic Lactacidosis

  • Santa Liga Starostniece (Speaker)
  • Anda Grigāne (Co-author)
  • Voicehovska, J. (Co-author)
  • Kaspars Kivlenieks (Co-author)

Activity: Talk or presentation types › Poster presentation

Description

Background: Metformin-associated lactic acidosis is a rare but a high mortality metabolic state for people with type 2 diabetes mellitus (DM2) and present kidney damage. Blood pH lower than 6.8 is not compatible with life, however, with modern treatment possibilities like continous hemofiltration (CVVH) there is a possibility to treat the patient and partially restore their kidney function resulting in a positive prognosis. Objective: The objective is to determine how acute CVVH can change the outcome in severe metformin-associated lactic acidosis compared to conservative therapy. Case presentation: A 71-year woman was admitted to Riga East Clinical University Hospital. The patient had been physically weak for about a month, had reduced apetite and has slimmed 18 kg. She was dizzy, couldn`t speak properly and had hallucinations. Patient had repeated bouts of vomiting and diarrhea the day before after which her condition worsened. Previous recorded ilnesses – CKD IIIA (GFR 53.12 ml/min july 2020.), DM2, non-insulin dependant, coronary heart disease, PAH with TODs. Objectively her condion is very serious. BP 110/60 mmHg; Cor 78x/min, rythmic. Oliguria. The patient is responsive but disoriented, confused. Mucous membranes are dry. Blood pH is
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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