Mutations within the chemokine receptor CCR2 gene coding region in patients with chronic lymphocytic leukemia

Description

In CCR2, 95 variants were detected once among 865 clones. 49% of CCR2 clones (425/865 in 55 patients) contained at least one of eight identified repetitive SNVs.. Gene analyses depicted 2.3-fold higher random mutation rate in CCR1 compared to CCR2 (25.3 random variants within CCR1 in 100 clones and 11.0 random variants within CCR2 in 100 clones). Eight SNVs have been identified repeatedly within CCR2, one of the most frequent ones is classified as benign in the ClinVar database. Further association of the identified CCR2 repeated SNVs with the patient clinical course of the CLL disease will allow to assess the diagnostic significance of each variant.

Period	29 Mar 2023 → 31 Mar 2023
Event title	RSU International Research Conference 2023: Knowledge for Use in Practice
Event type	Conference
Organiser	Rīga Stradiņš University
Location	Riga, LatviaShow on map
Degree of Recognition	International