Obstructive Sleep Apnoea Effect on Carotid Intima Media Thickness in Patients Hospitalised with Ischemic Stroke

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Description

Determine how different polygraphic parameters in patients with obstructive sleep apnea (OSA) are associated with carotid intima-media thickness (CIMT) and ischemic stroke severity.. In this prospective study 31 patients hospitalised with ischemic stroke were examined with polygraphy and carotid artery doppler ultrasonography. During hospitalisation patient stroke severity was assessed with National Institute of Health Stroke Scale (NIHSS). During doppler ultrasonography CIMT was assessed on a.carotis communis posterior wall 1 cm below carotid artery bifurcation, also stenosis on symptomatic side in corresponding vascular territory was recorded. Following parameters were determined in polygraphy: apnea index, hypopnea index, apnea-hypopnea index (AHI), lowest saturation during polygraphy, avarage saturation, desaturation index, heart frequency and heart rate variability index. OSA severity was determined by AHI. For data analysis Microsoft Excel and IBM SPSS 26 was used.. In patients that participated in study median age was 66 years (IQR 58-76). Most prevalent etiologies of ischemic stroke were cardioembolic stroke 41.9% (N=13) and atherothrombotic stroke 22.6% (N=7). Mostly patients had partial anterior circulation strokes 71% (N=22), of those most prevalent were a.cerebri media sinistra 38.7% (N=12) and a.cerebri media dextra 29.0% (N=9) location strokes. In this research CIMT did not show statistically significant correlation using Spearman correlation analysis with any polygraphic parameters. On the other hand Spearman correlation analysis showed statistically significant moderate degree of association between symptomatic circulatory region and polygraphic hypopnea index r(16)= 0.594, p=0.015 and desaturation index r(16)= 0.532, p= 0.034. . This research did not find statistically significant association between CIMT and polygraphic parameters in patients with OSA, although this possibly could be because of small sample size and due to limitations on ultrasonographic assessment. It was found that hypopnea index and desaturation index showed statistically significant correlation with symptomatic stenosis degree.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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