Optic Pathway Glioma Treatment Challenges over the Time – one Institution Experience: Case Series

  • Sandra Baltvilka (Speaker)
  • Kristiāna Blisiņa (Co-author)
  • Kovaļova, Ž. (Co-author)
  • Sandra Valeiņa (Co-author)

Activity: Talk or presentation types › Poster presentation

Description

To understand better the natural history of optic pathway glioma (OPG) in patients with neurofibromatosis type 1 (NF-1), and to evaluate the current recommended guidelines for monitoring and follow-up of OPG and the impact of chemotherapy in this population.. This retrospective case series included patient records of ophthalmological symptoms, MRI data, and chosen treatment method of OPG from the 2002- 2022 year. Children younger than 18 years diagnosed with OPG were included in the study. . In total, 56 patient medical records were conducted. OPG was diagnosed in 22 patients. Out of 22 patients with OPG 20 underwent the ''watch and wait'' strategy. 2 of the OPG patients underwent chemotherapy. In one of the cases, chemotherapy included vincristine alone, and in the second case initial cycle also included one-time administration of actinomycin D. Both patients presented with large spreading OPG. After chemotherapy tumor growth has significantly decreased allowing us to save the globe and not initiate surgical treatment or radiotherapy of the tumor. OPG is rare and difficult to treat tumor. Early recognition of present OPG and visual deterioration is crucial for the initiation of chemotherapy. Historically, radiation therapy was the treatment of choice for OPG, but it brought up severe complications including secondary tumors and Moya-Moya disease in patients with NF-1. Children with radiologically notable OPG must be evaluated by a multidisciplinary team – oncologist, ophthalmologist, and radiologist. In Latvia to achieve this kind of evaluation all children with NF-1 should be observed at Children’s Clinical University Hospital.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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