Peroral Disease-Modifying Drug Compliance among Patients with Multiple Sclerosis in Riga East Clinical University Hospital Multiple Sclerosis Unit

Activity: Talk or presentation types › Oral presentation

Description

The aim of the study was to analyse the adherence to oral DMT and factors influencing it, as well as treatment outcomes in MS patients.. In cross-sectional study 37 MS patients from Riga East University Hospital with prescribed peroral DMT were enrolled. Patients responded to a questionnaire about adherence, and completed a Symbol Digit Modalities Test (SDMT). Magnetic resonance imaging (MRI) and Expanded Disability Status Scale (EDSS) were performed. The data was analyzed using SPSS.. The study included 22 (59%) women. Mean age was 40,1 years (SD 11,234). Median range of an average missed doses (AMD) per year was 0.5, with maximum – 80 times per year. 26 (70%) patients at least once missed a dose. 42.3% of them (n-11) missed 1-2 doses for all treatment period, 38.5% (n-10) missed 3-5 doses, and 19.2% (n-5) missed doses regularly. 6 patients (16.2%) answered that it is difficult to use the DMT every day. Mean number of new lesions in the last MRI was 1,14 (SD 1,686), and the mean number of relapses for the past year was 0,43 (SD 0,647), 24 patients (64.9%) had no relapses during the last year, 10 (27%) had 1 relapse during the last year, and 3 patients (8.1%) had 2 relapses. A difference was found between  genders  in AMD per year (men>women), p=0.049. The distribution of AMD per year was the same in group of patients, who had a relapse during the last year and who had not. There was no correlation found between AMD per year and SDMT score, EDSS score, the number of new lesions in the last MRI.. Our study data shows that non-compliance to DMT is more common in men. There is no correlation between patient’s adherence and SDMT score, EDSS score, and the number of new lesions in the last MRI.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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