Persistent/Chronic Viral Co-infections In COVID-19 Patients In Latvia

Activity: Talk or presentation typesPoster presentation

Description

Objectives. Several SARS-CoV-2 peak protein heptapeptides have been shown to have similarity to human proteome heptapeptides, which apparently explains the autoimmune nature of this SARS-CoV-2. Co-infections have been reported in severe acute respiratory syndrome (SARS) patients but there is limited information on coinfections by other viruses triggering autoimmunity in
COVID-19 patients. In view of the above, the impact of existing co-infections on the clinical manifestations of COVID-19 patients cannot be ruled out, therefore we analysed the presence of 12 persistent/chronic viral infection markers in biological samples from COVID-19 patients in Latvia. Materials and Methods. In total 92 [41 (44.6%) male, median age 61 years; 51 (55.4%) female, median age 65 years] hospitalized COVID-19 patients were included. Presence of 12 viral genomic sequences in 92 DNA samples isolated from peripheral blood mononuclear cells (PBMC) and cell-free blood plasma was tested by multiplex PCR (Allplex Respiratory Panel 4, Allplex Meningitis-V1 Assay and Allplex Meningitis-V2 Assay, Seegene Inc., Republic of Korea). Results. In total 30 out of 92 (32.6%) PBMC samples were Epstein-Barr virus positive, 17 out of 92 (18.5%) samples were human herpesvirus 7 positive and one sample – human herpesvirus 6 positive. No plasma samples were positive for any of the viruses tested. For 6 (6.5%) patients, co-infection of Epstein-Barr virus and human herpesvirus 7 was detected, and for one patient – Epstein-Barr virus and human herpesvirus 6. Conclusions. Epstein-Barr virus is the most common chronic/persistent co-infection among hospitalized COVID-19 patients in Latvia, followed by human herpesvirus 7 infection. Given that all these herpesviruses are also triggers for autoimmune diseases, it is possible that their co-infection
with SARS-CoV-2 may affect the course of the disease, making it more severe and triggering autoimmune processes. (445539 3min News).
Period16 Jun 202118 Jun 2021
Event titleThe First Conference of the Society for Virology: Tackling Global Viral Epidemics
Event typeConference
OrganiserWorld Society for Virology
Degree of RecognitionInternational