Possible Contribution of Synovial Low-Grade Inflammation to Cognitive Impairment in Patients with Osteoarthritis

Activity: Talk or presentation types › Poster presentation

Description

To establish a possible association between synovial inflammation, pain, disability, and cognitive impairment confirmed in osteoarthritis (OA) patients using a morphological assessment tool proposed by Krenn and the cognitive screening test MOCA. . Patients with late stage hip or knee OA and who do not present with comorbidities (myocardial infarction, diabetes, strokes, severe atherosclerosis, and metastatic cancer in anamnesis) were recruited in the study. Twenty biopsy samples obtained during knee/hip endoprosthesis surgery were fixed in formalin and then paraffin-embedded. Sections were stained with hematoxylin and eosin and assessed using the grading system proposed by Krenn. Cognitive function analysis was performed using Montreal Cognitive Assessment (MoCA). Pain level was analyzed using a visual analog pain scale (VAS). The patient’s functional status was analyzed using the VAS and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Data were presented as median values with interquartile range (IQR).. The patients’ median age was 65 (36-75) years. The WOMAC value was 49.5 (42;53). The confirmed VAS median value was 7 (3;10), whereas Krenn score median value was defined as 3 (0; 7). Three OA patients presented with mild cognitive impairment (20, 21, and 24, respectively). The confirmed WOMAC in these patiemts was low to mild (21, 44, and 56), whereas the VAS score for these patients was (4; 7; 7), and the histopathological score was low (3,3,0). Statistically, the correlations between the WOMAC score and MoCA, as well as the Krenn and MoCA score were not established. . The possible associations between synovial low-grade inflammation and cognitive impairment in patients with OA were tested using a small-sized cohort. Statistically significant correlations were not found. Further studies should be applied using a larger number of subjects. Disease phenotypes should be considered.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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