Presentation/Lecture by Dr Vivek Trivedi

Description

Carbon dioxide (CO2) is the most commonly used supercritical fluid because of its relatively mild operating conditions (31.1°C and 72.8 bar) and easily tuneable properties. Moreover, the ability of CO2 to act as a solvent, solute, and plasticiser has made it highly desirable in the field of excipient processing, particle formation, and drug encapsulation. The dissolution of CO2 is known to affect the glass transition or melting temperature of numerous polymers and fats. This presentation provides an overview of the applications of scCO2 primarily as a solute or plasticiser and how it can be employed to manipulate excipients’ properties to develop various pharmaceutically important systems. The presentation includes examples of melting point depression caused by the dissolution of scCO2 in the crystalline matrix, solvent-free preparation of drug cyclodextrin complexes, drug loading in organic and inorganic excipients, and formation of pharmaceutical salts amongst others.
The application of scCO2 provides an excellent green platform for the preparation of drug delivery systems which can either completely avoid the need for organic solvents or reduce their usage during processing. These types of processing strategies are important not only from the environmental perspective but can be crucial to address concerns related to the residual solvents in the final dosage form. The scCO2 can be used as a solvent, antisolvent and additive to develop various formulations in an organic solvent, oxygen, and water-free environment. Formulations such as solid dispersions and drug-cyclodextrin complexes can be easily prepared in scCO2 using its additive properties to lower the melting/glass transition temperature of APIs and excipients.
This presentation aims to provide an overview of the approaches developed/applied in our lab to develop formulations using scCO2 as a media.

Period	20 Aug 2024
Event type	Lecture
Location	Riga, LatviaShow on map
Degree of Recognition	International