Relationship between Low-Density Lipoprotein Cholesterol and Severity and Outcome of the COVID-19 Disease

  • Jekaterina Pirkina (Speaker)
  • Umnova, L. (Co-author)
  • Natālija Nikrus (Co-author)

Activity: Talk or presentation types › Poster presentation

Description

From 2020 the world is living under the conditions of COVID-19 pandemic. Currently, more than 600 million cases of COVID-19 infection have been registered in the world, according to WHO data from December 2022, more than 6.5 million people died. But despite the global pandemic, people have co-morbidities, such as coronary heart disease, which is still one of the most common causes of death in Latvia. Low-density lipoprotein cholesterol is known to be one of the risk factors for coronary heart disease, but how this affects the course, severity, and outcome of COVID-19 is unknown. Currently, there is not enough data on the topic of this work in Latvia.The main purpose of this retrospective study was to find relationship between low-density lipoprotein cholesterol and the severity and outcome of COVID-19 disease. This retrospective study was conducted at the Pauls Stradins Clinical University Hospital, Riga East University Hospital and involved adults >18 years old who were hospitalized during the period from 01 October 2021 to 31 March 2022 with laboratory-confirmed COVID-19 infection and laboratory-determined low-density lipoprotein cholesterol. Clinical data and results were collected from medical records using MS Office Excel and analysed using SPSS program. . A total of 189 patients were included, 64,4 % were women and 35,6%- man. 173 patients survived and 16 died. There was no statistically significant difference in distribution of low-density lipoprotein cholesterol between surviving and deceased patient groups (Mann-Whitney U test, p=0.438). There was no found statistically significant correlation (Spearman’s rank correlation, p=0.700) between low-density lipoprotein cholesterol and the severity of COVID-19 disease.. The results of the study show that low-density lipoprotein cholesterol levels were not associated with disease severity and outcome of COVID-19. Further prospective research should be done in this area.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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