Review of a Plasma Exchange Procedure in Department of Neurology at Pauls Stradins Clinical University Hospital in 2022

Activity: Talk or presentation types › Poster presentation

Description

Plasma exchange procedure (PEX) is a therapeutic intervention involving extracorporeal removal, return, or exchange of blood plasma or components. PEX results in a filtered plasma product that is used for the treatment of numerous diseases including central nervous system (CNS) and peripheral nervous system (PNS) pathologies. The aim of this study was to determine indications, analyse efficacy and side effects during PEX in Department of Neurology at Pauls Stradiņš Clinical University Hospital (PSCUH) in 2022.. Retrospective analysis of patients who received PEX procedure in Department of Neurology at PSCUH from 01.01.2022. to 31.12.2022. We analysed patient files and daily recordings, evaluating indications for PEX treatment, clinical outcome, and experienced side-effects.. Totally 15 patients were included in the study - 8 men and 7 women. The mean age of patients was 57±12 years. 9 patients (60,0%) received PEX procedures during acute hospitalization, 6 patients (40,0%) – during planned hospitalization. 1 patient received PEX because of CNS disorder (autoimmune encephalitis), but 14 patients (93,3%) were treated with PEX because of PNS disease – 7 patients (46,7%) had myasthenia gravis, 2 patients – acute polyradiculoneuritis, 2 patients - chronic inflammatory demyelinating polyneuropathy, 1 patient - multifocal motor neuropathy, 2 patients - rapidly progressive demyelinating polyneuropathy. 4 patients received PEX during previous hospitalizations. Patient revaluation after PEX course showed improvement of neurological symptoms in 14 patients (93,22%). 4 patients had PEX related complications - 2 patients had allergic reaction to fresh frozen plasma, 2 patients had central venous catheter-related complications – 1 patient had catheter thrombosis and pulmonary embolism, 1 patient developed catheter-related infection and sepsis. . PEX is an effective therapeutic intervention used for treatment of both CNS and PNS pathology. Our experience shows that majority of patients improved on PEX. However, careful patient selection should be performed because of potential life-threatening treatment-related complications.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

Related content