Right Atrial Morphology in Coronary Heart Disease and Degenerative Aortic Valve Stenosis

Activity: Talk or presentation types › Oral presentation

Description

Coronary heart disease (CHD) and degenerative aortic valve (AoV) stenosis have common risk factors. However, these conditions are not always observed at the same time. This confirms the existence of risk and pathogenesis factors specific to each disease. Aim of the study: to determine the distribution of markers of apoptosis, homeostasis regulating factors, innervation, ischemia and inflammation in right atrial tissue in cases of CHD and degenerative AoV stenosis.. During elective cardiac surgery, right atrial tissue fragments were obtained from 24 patients with CHD and 12 patients with degenerative AoV stenosis. The control group – right atrial tissue fragments from 5 patients operated for congenital heart disease. Tissues were stained with hematoxylin and eosin for routine light microscopy, treated with the biotin-streptovidine method for immunohistochemical detection of tissue markers (atrial natriuretic peptide (ANUP), PGP 9.5-containing innervation, vascular endothelial growth factor (VEGF), chromogranin A (ChgA), endothelin 1 (ET-1), interleukin 1α (Il-1α ), interleukin 10 (II-10), β defensins 2, 3 and 4 (βD2, βD3 and βD4, respectively)) and by the TUNEL method for the detection of apoptotic cells. For the quantification of structures, a semi-quantitative counting method was used.. Right atrial tissue in both CHD and degenerative AoV stenosis is characterized by non-specific degenerative morphological changes and a high proportion of apoptotic cardiomyocytes. Connective tissue ingrowth and vascular sclerosis were observed in some patients in both groups. Patients with CHD and AoV stenosis had significantly more ANUP, IL-10, βD2 and βD3-positive cells, but fewer ChgA-positive cells than controls. The rich expression of antimicrobial peptides was observed in all study groups.. In both groups of acquired heart disease, an anti-inflammatory and antimicrobial response prevails in the right atrial tissue, but increased activity of the neuroendocrine system is more common in patients with congenital heart disease.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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