Role of Anti-Nuclear and Anti-Ganglioside Antibodies in Pathogenesis of Polyneuropathy in Systemic Sclerosis

Activity: Talk or presentation types › Poster presentation

Description

Systemic sclerosis (SSc) is an autoimmune connective tissue disease. Polyneuropathy (PNP) is considered a rare SSc complication but can significantly affect patients' quality of life. The current study aimed to assess different antinuclear antibodies (ANA) patterns and anti-ganglioside antibodies (AGA), and their role in PNP pathogenesis. . The study included 2 groups: SSc patients with PNP (24) and without (24), with matching gender and age ratio. The indirect immunofluorescence test was performed to assess the presence and pattern of ANA, and ELISA was used for AGA detection. . In both groups, there were 18 females and 6 males, mean age in females was similar: 69.5 with PNP, 67 without PNP, but males without PNP were much younger than those with: 70.5 with PNP, 46.33 without. ANA were detected more in patients with PNP (21/24 vs 15/24, p= 0.0933), but the distribution of patterns of ANA were quite similar in both groups: most common was centromere (9/24 vs 8/24), next was speckled (9/24 vs 7/24), but homogeneous and nucleolar patterns were seen only in PNP group: 2/24 and 1/24 respectively. 24 patients with PNP were tested for the presence of AGA, and 3 (12.5%) had positive AGA, compared to data from other AGA studies, where positive antibodies were found in 15,5% of healthy individuals. There was no association between the presence of ANA (p = 0.0933) or ANA different patterns (p = 1.000) and AGA.. ANA and different patterns were not found to be relevant in the pathogenesis of PNP in SSc AGA can be found positive in patients with SSc-associated PNP, for their significance in SSc a larger sample size should be tested.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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