Description
OBJECTIVES:Oral lichen planus (OLP) is the most common non-infectious, chronic inflammatory oral disease affecting 1-2% of the general adult population. Its aetiology is unknown, however there is some information on the involvement of EBV in the aetiology of OLP. The aim of the study was to evaluate the association of EBV and OLP based on virus specific IgG class antibody level in serum and viral load in saliva.
MATERIALS AND METHODS:
22 patients, ages between 18-75, who visited Centre of Oral Medicine were included in the study. The diagnosis was confirmed by histopathological investigation of the lesions. Saliva samples were taken on the first visit and stored at -80 degrees which were later transported to the Institute of Microbiology and Virology, for real time PCR. Also, the patients were requested to get their serum IgG class antibody level for EBV evaluated.
RESULTS:
3 patients had reticular form of OLP and 9 erosive form. Out of 22 patients 21 were anti-EBV-IgG seropositive however, not all the patients showed EBV presence in saliva. Saliva samples of 13 patients were EBV PCR positive and 10 of them where patients with reticular form of OLP, moreover 4 of these patients had viral load more than 105 EBV copies/ml saliva. The obtained results suggest that EBV infection is associated with or is the trigger factor in oral lichen ruber planus development.
CONCLUSION:
The results of this pilot study suggest that EBV infection is associated with increased risk of OLP. However, these results are preliminary, and larger‐scale study is required to draw global conclusion on the role EBV in OLP pathogenesis
Džagriti Kakare1, Lība Sokolovska2, Modra Murovska2, Ingrīda Čēma1
1Centre of Oral Medicine, Institute of Stomatology, Riga Stradins University, Riga, Latvia
2Institute of Microbiology and Virology, Riga Stradins University, Riga, Latvia
OBJECTIVES:
Oral lichen planus (OLP) is the most common non-infectious, chronic inflammatory oral disease affecting 1-2% of the general adult population. Its aetiology is unknown, however there is some information on the involvement of EBV in the aetiology of OLP. The aim of the study was to evaluate the association of EBV and OLP based on virus specific IgG class antibody level in serum and viral load in saliva.
MATERIALS AND METHODS:
22 patients, ages between 18-75, who visited Centre of Oral Medicine were included in the study. The diagnosis was confirmed by histopathological investigation of the lesions. Saliva samples were taken on the first visit and stored at -80 degrees which were later transported to the Institute of Microbiology and Virology, for real time PCR. Also, the patients were requested to get their serum IgG class antibody level for EBV evaluated.
RESULTS:
3 patients had reticular form of OLP and 9 erosive form. Out of 22 patients 21 were anti-EBV-IgG seropositive however, not all the patients showed EBV presence in saliva. Saliva samples of 13 patients were EBV PCR positive and 10 of them where patients with reticular form of OLP, moreover 4 of these patients had viral load more than 105 EBV copies/ml saliva. The obtained results suggest that EBV infection is associated with or is the trigger factor in oral lichen ruber planus development.
CONCLUSION:
The results of this pilot study suggest that EBV infection is associated with increased risk of OLP. However, these results are preliminary, and larger‐scale study is required to draw global conclusion on the role EBV in OLP pathogenesis
| Period | 20 Jan 2023 |
|---|---|
| Event title | 2023 IADR NOF Baltic Meeting in Oral Health Science & Technology |
| Event type | Meeting |
| Organiser | Scandinavian Division of the International Association for Dental Research (IADR) |
| Location | Vilnius, LithuaniaShow on map |
| Degree of Recognition | International |
Field of Science
- 3.2 Clinical medicine