Role of Microbiome in Pathogenesis of Immunoglobulin A Nephropathy

Activity: Talk or presentation types › Oral presentation

Description

Recent years studies indicate the importance of gut-kidney axis in the pathogenesis of immunoglobulin A nephropathy (IgAN). Progression of IgAN has been associated with gut dysbiosis and bacterial translocation. The gut microbiome is dynamic and varies in different populations, ages, sexes, seasonal variations, geographies, ethnicities, diets, and lifestyles.. Project  “Dissecting the interplay between intestinal dysbiosis and B cell function in the pathogenesis of immunoglobulin A Nephropathy" No. lzp-2019/1-0139 funded by the Latvian Council of Science, has started the implementation in Pauls Stradiņš Clinical University Hospital in January 2020. Adults with a morphologically confirmed IgAN and healthy individuals were included in the study. Gut microbiota of fecal samples of IgAN patients and healthy controls were analyzed using 16S rDNA sequencing.. Our projects results will follow this year. According to other studies, the genera, Streptococcus and Paraprevotella showed a higher proportion in patients with IgAN compared to healthy individuals, whereas Fusicatenibacter showed a lower abundance according to meta-analysis. Qualitative analyses suggested that Escherichia-Shigella might be increased in IgAN patients. Two multicenter placebo-controlled trials (the phase 2b NEFIGAN and the phase 3 NefIgArd studies) showed clinically important improvements in proteinuria and glomerular filtration rates in IgAN patients who were treated with targeted-release budesonide.. Gut microbiome represents a novel therapeutic target for improving the outcome of IgAN.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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