Short and Mid-Term Outcomes of Multysystem Inflammatory Syndrome in Children (MIS-c): Prospective Longitudinal Cohort Study

    Activity: Talk or presentation types › Oral presentation

    Description

    To determine short and mid-term outcomes of MIS-c in children. . Prospective longitudinal cohort study. Children under age of 18 years, fulfilling the Centers for Disease Prevention and Control (CDC) diagnostic criteria for MIS-c, and admitted to Children’s Clinical University Hospital of Latvia (CCUH), between July 1, 2020, and April 15, 2022, were enrolled. All patients were evaluated at various time points: 2 weeks, 2 months (1-3 months), and 6 months (5-7 months) after MIS-c diagnosis.. 21 patients with confirmed MIS-c were included. The median age of the study group was 6 years, (Interquartile range (IQR), 5-10 years; range, 1-16 years), 52.4% (N=11) were girls. Only 71.4 % (N=15) of patients had confirmed SARS-CoV-2 infection (positive PCR test) prior MIS-c. At 2-week follow-up majority of complaints were associated with decreased physical activity- 10 children (47.6%) reported exercise intolerance with provoked tiredness, three children (14.3%) had difficulties to walk for more than 15 minutes or climb stairs. Laboratory tests showed increase in blood cell counts with a near doubling of leukocyte and neutrophil counts and tripling of thrombocyte levels. At 3 months follow-up 5 patients (23.8%) reported increased appetite and weight gain. 5 children (23.8%) still had physical activity provoked tiredness with only 2 children (9.5%) reporting decreased physical activity tolerance. 2 children (9.5%) had periodically prolonged elevated body temperature (up to 37.60 C) without any other complaints. Normalisation of all blood cell lines was seen in repeated testing. At 6 months visit 4 children (19%) still showed progressive weight gain, while 2 patients (9.5%) had decreased physical activity tolerance. Reduction in physical activity provoked tiredness was observed, comparing with 1-3 months follow-up. There were no pathological changes in repeatedly performed laboratory tests.. Abnormal clinical and laboratory findings were seen in patients 2 weeks after MIS-C with significant improvement in following weeks.
    Period29 Mar 2023
    Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
    Event typeConference
    OrganiserRīga Stradiņš University
    LocationRiga, LatviaShow on map
    Degree of RecognitionInternational

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