Significance of Clinical Presentations in the Course of the Immunoglobulin A Nephropathy (IgAN)

Activity: Talk or presentation types › Oral presentation

Description

IgAN is believed to be the most common type of glomerulonephritis worldwide. However, there are considerable variations in the prevalence, clinic presentation, and prognosis of IgAN in different geographic areas. Similarly to Western Europe, in Latvia, IgAN has a moderate prevalence in 2013 (23%) among all kidney biopsies (KB) in Pauls Stradins Clinical University Hospital Nephrology Centre. An analysis of the clinical manifestations of IgAN is one of the important strategies in the course of the disease. This would allow a better understanding of the pathogenesis and treatment of IgAN, and prevent premature kidney death.. This research is funded by the Latvian Council of Science (No. Izp-2019/1-0139). From January 2020 to March 2021 adult patients with morphologically proven primary IgAN were enrolled in the study. We studied a main clinical presentation of IgAN (hematuria; proteinuria; arterial hypertension, course of chronic kidney disease (CKD). KBs were analysed according to Oxford classification (MEST-C). We evaluated leucine-rich alpha-2-glycoprotein (LRG1) in serum and urine as a marker of kidney damage.. A total of 80 patients with IgAN were included, 65% men. The median age was 40 years (21-65). The patient subset according to the stage of CKD was 21%, 19%, 14%, 16%, in stages 1,2,3,4 respectively, with dialysis – 11% and kidney transplant -19%. The MEST-C score was M0-22.5%, M1-77.5%; E0-92.2%, E1-7.8%; S0-27.5%, S1-72.5%; T0-73.5%, T1-13.8%, T2-12.5%; C0-88.8%, C1-7.5%, C2-3.8%. More than 50% of the subjects had hypertension, proteinuria, obesity, and eGFR
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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