The effect of disease aggressiveness and activity on the development of fatigue in patients with rheumatoid arthritis

Activity: Talk or presentation typesPoster presentation

Description

Background and Aims: Fatigue is very common in rheumatoid arthritis (RA) patients. It affects around 40–80% of these patients. Fatigue is one of the most commonly reported symptoms,associated with pain, depression and anxiety, and affecting function, work and quality of life. This study aimed to determine the development of fatigue depending on proinflammatorycytokines in RA patients.
Methods: Overall 30 RA patients: 23 females (76.7%), 7 males (23.2%) with average age 59.5±11.2 (ranging from 39 to 79) were included in the study, interviewed using adapted interview questions created by Minnock et.al. (2016). The level of the proinflammatory cytokinesTNF-α, IFN-g, IL-2, IL-6, IL-17and IL-23 was determined by ELISA test.
Results: Based on the results of the survey, RA patients were divided into two groups - with and without fatigue. In RA patients with fatigue an increase in the level of IL-6 correlate with an increase in the level of IFN-g, IL-17 and TNF-α, respectively, as well as an increase in the level of IL-21 and a decrease in the level of TNF-α. In the non-fatigue group, positive correlation between an increase in the level of IL-21 and an increase in the level of IFN-g, IL-17 and IL-2, as well as between an increase in the level of TNF-α and an increase in the level of IL-2, IL-21 and Il-23 was observed.
Conclusions: Study data suggest that only IL-6 do not significantly affect the development of fatigue in RA patients.
Period16 Mar 2023
Event title7th International Congress on Controversies in Rheumatology & Autoimmunity
Event typeConference
Conference number7
LocationTurin, ItalyShow on map
Degree of RecognitionInternational