Tissue phenomena and their possible explanation

Activity: Talk or presentation typesOral presentation


Phenomena means something (such as an interesting fact or event) that can be observed and studied and that typically is unusual or difficult to understand or explain fully. We aimed to detect four tissue phenomena like an unusual epithelial processes, tissue factors patterning, cellular shape/phenotype changes, and tissue replacement capacity.. The material of oral cavity, heart, serosal membranes, vocal cords was obtained from around 700 patients of different age with different diagnosis during 2021-2022. Genes/gene proteins, growth factors/their receptors, remodelation factors, and proliferation markers were researched immunohistochemically.. Unusual network-like processes of the germinative layer were detected in oral stratified squamous epithelium richly presenting HoxB3, NGFR, FGFR1, while NGF, bFGF, Msx were expressed indistinctly here, but Ki-67 was absent at all. This was seen in 40 patients (out of 400) with cleft lip palate. Ki-67 showed strict epithelial appearance from zero to abundant in patients with singer nodules, cleft, lung diseases. Epithelium and connective tissue demonstrated MMPs/TIMPs appearance with solitarily increased one/or the other, and equal expression of both factors in cleft and adhesions. Mesothelium, epicardium and fibroblasts demonstrated changed cellular shape from flattened to round one along with the rich expression of different factors in adhesions and heart diseases. Angle II/III skeletal dysplasia patients demonstrated empty from BarX1 bone, while oral epithelium richly expressed this gene.. The presence of tissue phenomena does not depend on age. Stratified squamous epithelium network-like processes show stimulated growth properties (HoxB3, NGFR, FGFR1) and probably are the result of prolonged inflammation. The common phenomenon is tissue proliferation and remodelation factors patterning with three variations in their distribution coexisting to tissue functionality. Changes in cellular shape mainly suggests the possible phenotype changes of cells. Tissue replacement phenomenon means the expression of factors in one tissue type typically being expressed by the other type.
Period30 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionNational