Description
Triple-negative breast cancer (TNBC) is a particularly notable breast cancer subtype due to its aggressive, heterogeneous, and refractory nature, along with limited treatment options, posing a significant challenge to clinical management.One of the hallmarks of many cancers, including TNBC, is resistance to apoptosis, which can occur through the downregulation or inhibition of pro-apoptotic proteins or the upregulation of anti-apoptotic proteins.
Hypoxia, a common feature of solid tumours, has been linked to increased invasiveness, malignant progression, and death evasion mechanisms that contribute to therapy resistance. The severity and duration of hypoxia define the response and, thus, the subsequent signalling mechanisms initiated by the cancer cells.
Additionally, despite its widespread use as a control in hypoxia studies, atmospheric oxygen (21% O₂) does not accurately reflect the oxygen
concentrations found in human tissues. Physiological oxygen levels, known as
physoxia, typically range from 4.6% to 9.5%, with breast tissue exhibiting an oxygen level of about 8%. Thus, using physoxia as a control is essential for replicating physiologically relevant conditions and enhancing the translational value of hypoxia research.
Here, we explore the induction of apoptotic priming and apoptotic dependencies in TNBC cell lines under physoxia, acute and chronic hypoxia.
| Period | 18 Jun 2025 |
|---|---|
| Held at | The European Association for Cancer Research, United Kingdom |
| Degree of Recognition | International |