Ultrasound Guided Neddle Biopsy to Evaluate Nodal Metastasis after Preoperative Systemic Therapy in Different Breast Cancer Subtype Groups

Activity: Talk or presentation types › Poster presentation

Description

Aim of the study is to evaluate the role of ultrasound guided fine needle aspiration cytology (FNAC) in the restaging of node positive breast cancer after preoperative systemic therapy (PST) in diferent breast cancer subtype groups. . From January 2016 - October 2020 158 node positive stage IIA-IIIC breast cancer cases undergoing PST were included in the study.  After PST restaging of axilla was performed with ultrasound and FNAC of the marked and/or the most suspicious axillary node.Study cases were divided into following breast cancer subtype groups- HER2+, Triple negative, Luminal A (Ki67 10%). The overall false positive rate (FPR) and false negative rate (FNR) of FNAC after PST in whole cohort was 43 and 18%, respectively. Overall sensitivity - 55%, specificity - 93%, accuracy 70%.In HER2+ group we include 37 cases (FNR 20%, FPR 0%). In Triple negative group include 19 cases (FNR 44%, FPR 0%), In Luminal A group we include 24 cases (FNR 14%, FPR 0%), Luminal B group 78 cases (FNR 43%, FPR 23%).. FNAC after PST has low FPR and is useful to predict residual axillary disease and to streamline surgical decision making regarding ALND.FNR is high in overall cohort and FNAC alone are not able to predict complete pathological remission after PST and omission of further axillary surgery. However, FNAC in breast cancer HER2+ and Luminal A subgroup is more promising and further research with larger number of cases is necessary to confirm the results. This study/research/work/publication has been developed with financing from the European Social Fund and Latvian state budget within the project no. 8.2.2.0/20/I/004 “Support for involving doctoral students in scientific research and studies”at Rīga Stradiņš University.
Period29 Mar 2023
Event titleRSU International Research Conference 2023: Knowledge for Use in Practice
Event typeConference
OrganiserRīga Stradiņš University
LocationRiga, LatviaShow on map
Degree of RecognitionInternational

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