Unlocking Bioavailability: Mesoporous Drug Carrier for Stable Amorphous Formulations

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Description

Drug solubility is a critical issue in formulation development, with many compounds facing risks due to poor oral bioavailability. Enhancing solubility is a major challenge for both new chemical entities and existing drugs. Mesoporous silica offers a solution by utilizing molecular adsorption and steric stabilization within its nanoconfined pores, to create stable and effective amorphous formulations. This approach is promising for improving the bioavailability of poorly soluble active pharmaceutical ingredients (APIs). The session will cover the mechanistic foundations of mesoporous silica, including lab-scale loading and scale-up potential, along with in vitro and in vivo case studies demonstrating its effectiveness for typical BCS II compounds.

In this webinar, you will learn:

An overview how mesoporous silica technology result in stable and effective amorphous formulations
Loading methods on mesoporous silica and their performance
Case studies of in vitro and in vivo performance of mesoporous silica formulations
How mesoporous silica can reduce the risk of re-crystallization of poor glass formers.
Period21 Jan 2025
Event typeWebinar
Degree of RecognitionInternational

Keywords

  • bioavailability
  • poorly water-soluble drug
  • Mesoporous silica microparticles
  • pharmaceutical technology
  • biopharmaceutical properties

Field of Science

  • 1.4 Chemical sciences
  • 2.4 Chemical engineering
  • 3.4 Medical biotechnology

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