Usage of Corticosteroids and Hospitalisation Duration in Adult Patients with Systemic Lupus Erythematosus (SLE) in Latvia

Activity: Talk or presentation typesPoster presentation


Background/Purpose: To determine the factors influencing hospitalisation duration, re – hospitalisation (more than 1 hospitalisation during the study period), frequency of the usage of corticosteroids (CS) and its correlation with SLEDAI, SLICC/ACR DI of systemic lupus erythematosus (SLE) patients.

Methods: A retrospective study performed from 01 January 2018 till 31 December 2019 analysed the data of 80 SLE patients, including hospitalisation episodes, in Pauls Stradins Clinical University Hospital.

Results: 70 (87.5 %) patients were females and 10 (12.5%) males. 44 (55 %) patients were admitted to the hospital due to SLE flare and 5 (6.3%) patients due to a new onset of SLE. The mean duration of hospitalisation was 6.8 days (SD 4,9). CS (the mean dosage of prednisolone was 12.6 mg (SD 16.1)) was used in 54 (67.5%) patients before hospitalisation. The proportion of re-hospitalised patients was higher among CS users in comparison with CS non-users (61.1% (n = 33) vs. 26.9% (n=7), p = 0.004). CS users were hospitalised due to infection in 9.3% vs. 0.0% in non-users. An overall infection rate as the reason of hospitalisation was increased in 24.4% CS users vs. 3.8% non-users, p< 0.05. The dose of CS correlated with SLICC/ACR DI (r=0.363, p=0.001), but did not correlate with SLEDAI (r=-0.192, p=0.089). Duration of hospitalisation was longer in case of infection (11.4 vs. 5.9 days, p = 0.000), serositis (9.4 vs. 6.2 days, p = 0.018), fever (8.9 vs. 4.7 days, p = 0.004) and neurolupus (7.4 vs. 3.4 days, p = 0.008). Hospitalisation duration had correlation with ESR (r = 0.284, p = 0.012), CRP (r = 0.323, p = 0.003), SLEDAI (r = 0.237, p =0.034), total count of leukocytes (r = -0.317, p = 0.004), and neutrophils (r = -0.287, p = 0.01).

Conclusion: The most common cause of hospitalisation in SLE patients was a flare. More than half of SLE patients in long-term treatment received CS with higher rate of hospitalisation and re-hospitalisation within a year due to infection.
Period7 Nov 2020
Event title American College of Rheumatology (ACR) Convergence 2020
Event typeMeeting
Degree of RecognitionInternational