Precipitation Profiles of Naproxen in Dissolution Media

This dataset contains raw UV absorbance values of naproxen at lambda max (330-334 nm, depending on the polymer), as well as normalised absorbance values (using readings at 850 nm for normalisation). UV spectra of naproxen was taken in a dissolution media consisting of HCl solution with pH 1.2 (prepared according to Ph. Eur.) supplemented with 2.4% acetonitrile (introduced with naproxen solution). The media additionally contained one of the following polymers: povidone (PVP K25), copovidone (Kollidon VA 64), poly (butyl methacrylateco-(2-dimethylaminoethyl) methacrylate-co-methyl methacrylate 1:2:1 (Eudragit E PO), polyacrylic acid (Apinovex LV), polyvinyl alcohol (PVAl; SRP, 4-88, and 3-82) at a concentration of 0.75 mg/ml (40:60 drug:polymer), and Soluplus at a concentration of 0.125 mg/ml (80:20 drug:polymer).
Method: A precipitation study was performed in 0.1 N HCl solution with pre-dissolved polymer (60, 40, and 20 wt. %). Naproxen solution in acetonitrile (20 mg/mL) to achieve the proportion of 500 mg of naproxen per 1 L of dissolution medium (0.5 mg/mL) was added. UV absorption was determined directly within 10 mm pathlength quartz cuvettes (at room temperature) with UV spectrophotometer (UV-1900i; Shimadzu Corp., Kyoto, Japan) Spectra were recorded at 5-minute intervals over a 2-hour period (n = 3), using the “Spectrum” or “Time Course” mode in LabSolutions software.
Data. The dataset contains a CSV file of naproxen UV-absorbance values in the presence of polymers. Picture “P1” provides a brief overview of data.