Institute of Microbiology and Virology

Active

Development of Postbiotics’ Compositions Including the Evaluation of Its Bioactivity Against Pathogenic Bacteria and Their Produced Biofilms in the Dairy Industry

Gulbe, G. (Project leader)

1/04/25 → 31/03/28

Project: EU Structural Funds › ERDF

Development and piloting of automation for analysis of the blood-brain barrier using deep neural networks

Skuja, S. (Project leader), Groma, V. (Work package leader), Edelmers, E. (Work package leader), Svirskis, Š. (Work package leader), Viguls, Ē. (Assistant (student)), Nigolasa, L. (Participant) & Gulbe, A. I. (Assistant (student))

1/04/25 → 31/03/26

Project: Consolidation grants

Ex Vivo Drug Screening Platform for Personalized Therapy of Metastatic Melanoma

Gerke, G. (Project leader), Doniņa, S. (Supervisor) & Pjanova, D. (Supervisor)

3/02/25 → 31/01/29

Project: Student projects

canServ user. Whole exome sequencing to advance melanoma early detection.

Pjanova, D. (Project leader) & Kreishmane, M. (Expert)

2/01/25 → 31/10/25

Project: Projects outside RSU

Digital monitoring for integrated progression assessment of myalgic encephalomyelitis / chronic fatigue syndrome

Berķis, U. (Project leader), Murovska, M. (Leading expert), Krūmiņa, A. (Leading expert), Grāvelsiņa, S. (Expert), Arāja, D. (Assistant (student)), Egle, J. (Assistant (student)) & Vilmane, A. (Expert)

Latvian Council of Science

1/01/25 → 31/12/27

Project: Fundamental and Applied Research Programme

DICE: Epigenomic regulation of cancer immunity by dietary intervention

F. Fraga, M. (Project leader) & Pjanova, D. (Partner's coordinator)

1/12/24 → 30/11/27

Project: EU Programmes › ERA-NET

Development of criteria for limiting nosocomial infections and optimization of healthcare resources with application algorithms and roadmaps

Vīksna, L. (Project leader), Plaudis, H. (Leading expert), Koļesova, O. (Leading expert), Eglīte, M. (Leading expert), Koļesovs, A. (Leading expert), Ivanovs, A. (Leading expert), Proskurins, J. (Expert), Madelāne, M. (Leading expert), Žilde, A. (Expert), Lakiša, S. (Expert), Paegle, D. I. (Expert), Lībere, L. (Expert), Jegorova, J. (Expert), Bērziņa, L. (Expert), Vaivods, R. V. (Assistant (student)), Novika , L. (Assistant (student)), Kaulakane, A. (Expert), Bantauska, D. (Expert), Jansone, V. (Other), Pulmanis, E. (Partner's coordinator), Liepiņš, M. (Other) & Niedre-Otomere, B. (Other)

1/11/24 → 31/03/26

Project: EU Structural Funds › Other

Unveiling SARS-CoV-2 Spike Protein's Role in Cellular Metabolism and Crosstalk with Herpesvirus Reactivation Using Novel 3D cell culture/organoid

Melderis, M. (Project leader), Prusty, B. K. (Supervisor) & Nora-Krūkle, Z. (Supervisor)

1/10/24 → 29/09/28

Project: PhD projects

Pathogenic role of SARS-CoV-2-induced herpesvirus reactivations in post-COVID symptoms and their relation to chronic fatigue syndrome.

Prusty, B. K. (Project leader), Waghmare, T. S. (Leading expert), Nikolayshvili, G. (Expert), Nora-Krūkle, Z. (Expert), Hollmann , C. (Expert) & Liu , Z. (Expert)

Amar foundation, USA

25/06/24 → 31/10/25

Project: Contract research › R&D project

EATRIS-CONNECT: EATRIS-CONNECT

Saunders, G. (Project leader), Nora-Krūkle, Z. (Partner's coordinator), Krūmiņa, J. (Expert), Kreišmanis, I. (Expert) & Ziemele, B. (Expert)

Horizon europe

1/05/24 → 30/04/27

Project: EU Programmes › Horizon Europe

Antimicrobial and wound healing properties of K21

Prusty, B. K. (Project leader), Waghmare, T. S. (Leading expert), Bašēns, E. E. (Expert) & Nora-Krūkle, Z. (Expert)

4/04/24 → 31/03/29

Project: Contract research › R&D project

Exploring the Autoimmune Dimensions of Fibromyalgia: Deciphering Microbiome, Viral Triggers, and Immunological Patterns to Promote a Patient-Centered Approach

Nora-Krūkle, Z. (Project leader), Murovska, M. (Leading expert), Sokolovska, L. (Expert), Ķēniņa, V. (Expert), Vilmane, A. (Expert) & Ostrinski, Y. (Expert)

Recovery and Resilience Facility

1/04/24 → 31/03/26

Project: Consolidation grants

TCReX: Tumour cell response to acute aerobic exercise in breast cancer survivors: modulatory effects of exercise type and intensity

Roelands, B. (Project leader), Dela, F. (Project leader), Gersone, G. (Project leader), Reihmane, D. (Work package leader), Kļaviņa, A. (Leading expert), Laizāne, L. (Expert), Zolova, A. (Expert), Mitre, I. (Expert) & Trošins, D. (Participant)

European Commission

1/04/24 → 31/03/26

Project: Consolidation grants

hip-TNBC: Hypoxia-induced molecular alterations and druggable targets in triple negative breast cancer cell lines - HipTNBC

Čakstiņa-Dzērve, I. (Project leader), Mitre, I. (Expert), Rogoza, O. (Assistant (student)) & Pirsko, V. (Work package leader)

Latvian Council of Science

1/01/24 → 31/12/26

Project: Fundamental and Applied Research Programme

Mitochondrial dysfunction and metabolic alterations in ME/CFS

Prusty, B. K. (Project leader)

1/08/22 → 31/07/25

Project: Projects outside RSU

Biomarker models for prediction of microvascular flap complications in reconstructive surgery

Ročāns, R. P. (Project leader), Doniņa, S. (Supervisor) & Mamaja, B. (Supervisor)

1/10/21 → 30/09/25

Project: PhD projects

Finished

Quantitative dsRNA assessement in the Larifan

Pjanova, D. (Project leader) & Kreishmane, M. (Expert)

22/02/24 → 27/02/24

Project: Contract research › Scientific services

Linking serum antibodies to exercise intolerance and muscle/neuronal fatigue in ME/CFS

Prusty, B. K. (Project leader)

1/09/23 → 30/09/24

Project: Projects outside RSU

From peripheral immune response to neuroinflammation: exploring causal links between human herpesvirus-6 infection and non-communicable diseases

Skuja, S. (Project leader), Svirskis, Š. (Participant), Rasa-Dzelzkalēja, S. (Participant), Groma, V. (Participant), Naumovs, V. (Participant), Jain, N. (Participant), Gulbe, A. I. (Participant), Kliemane, A. (Participant) & Nigolasa, L. (Participant)

Riga Stradins University

3/04/23 → 2/04/24

Project: RSU grants

Impact of bacteriophage-derived dsRNA on macrophages in the context of COVID-19 pandemic.

Pjanova, D. (Project leader), Skivka, L. (Project leader) & Vaivode, K. (Expert)

1/03/23 → 31/12/24

Project: Projects outside RSU

State research project in the field of biomedicine, medical technologies and pharmacy

Lejnieks, A. (Partner's coordinator), Karelis, G. (Leading expert), Gardovska, D. (Leading expert), Ābola, Z. (Leading expert), Miklaševičs, E. (Leading expert), Daneberga, Z. (Leading expert), Gardovskis, J. (Leading expert), Pētersons, A. (Leading expert), Kļaviņš, K. (Expert), Kroiča, J. (Leading expert), Skadiņš, I. (Leading expert), Vīksna, L. (Leading expert), Dimiņa, E. (Expert), Sniedze, D. (Participant), Karlsons, J. (Participant), Broks, R. (Participant), Gravele, D. (Expert), Rozentālberga, A. (Expert), Kanašniece, E. (Expert), Konrāde, I. (Leading expert), Trušinskis, K. (Leading expert), Strēle, I. (Leading expert), Kaļiņins, A. (Expert), Ķīvīte-Urtāne, A. (Leading expert), Radziņš, O. (Expert), Bāgante, I. (Leading expert), Koļesova, O. (Leading expert), Nora-Krūkle, Z. (Leading expert), Koļesovs, A. (Expert), Mičule, M. (Participant), Grāvelsiņa, S. (Expert), Rasa-Dzelzkalēja, S. (Leading expert), Kande, L. (Expert), Nakazawa (Miklasevica), M. (Leading expert), Vjaters, E. (Leading expert), Lietuvietis, V. (Leading expert), Plonis, J. (Leading expert), Bitiņa-Barlote, Ē. (Expert), Ieviņa, L. (Participant), Fortūna, K. (Expert (PhD student)), Pētersons, A. (Participant), Pastare, D. (Expert), Pugovičs, O. (Project leader), Silina, S. (Participant), Zemčugova-Bērziņa, A. (Participant), Tihomirova, Ļ. (Participant), Maļina, L. (Participant) & Kozačenko, J. (Participant)

Latvian Council of Science

1/12/22 → 30/11/24

Project: National Research Programme

Development of clinical algorithms and clinical pathways for dynamic observation of patients after COVID-19

Vīksna, L. (Project leader), Vanaga, I. (Expert), Pētersons, A. (Expert), Zeltiņa, I. (Expert), Kalējs, O. (Expert), Karelis, G. (Expert), Rezeberga, D. (Expert), Radziņa, M. (Expert), Vētra, A. (Expert), Storoženko, J. (Expert), Taube, M. (Expert), Lejnieks, A. (Expert), Lietuvietis, V. (Expert), Koļesova, O. (Expert), Liepiņa, E. (Expert), Kadiša, A. (Expert), Lejniece, S. (Expert), Bataraga, E. (Expert), Plaudis, H. (Expert), Višņakovs, A. (Expert) & Bantauska, D. (Expert)

Ministry of Health of the Republic of Latvia

24/05/22 → 24/11/22

Project: Contract research › R&D project

Identification of specific osteoarthritis phenotypes and disease endotypes tackled using the molecular and cellular assessment of the synovium-cartilage-bone interplay

Groma, V. (Project leader), Nora-Krūkle, Z. (Leading expert), Skuja, S. (Leading expert) & Svirskis, Š. (Leading expert)

Riga Stradins University

1/04/22 → 31/03/23

Project: RSU grants

Assessment of new biomarkers for the prognosis and treatment prediction in chronic lymphocytic leukemia

Holodņuka, I. (Project leader) & Pavlova, J. (Expert)

Riga Stradins University

1/04/22 → 31/03/23

Project: RSU grants

Fibromyalgia associated microbiome, viral infection and immunological profile

Nora-Krūkle, Z. (Project leader), Rasa-Dzelzkalēja, S. (Expert), Ķēniņa, V. (Expert), Svirskis, Š. (Expert), Grāvelsiņa, S. (Expert) & Vilmane, A. (Expert)

Riga Stradins University

1/04/22 → 31/03/23

Project: RSU grants

Human papillomavirus genome associated correlates of disease progression and treatment response for cervical neoplasms and cancer

Issagouliantis, M. (Project leader), Jansons, J. (Leading expert), Mitiļdžans, A. (Expert), Spridzāne, A. (Expert), Sokolovska, L. (Expert), Dudorova, A. (Expert (PhD student)) & Kiseļova, V. D. (Assistant (student))

Latvian Council of Science

3/01/22 → 30/12/24

Project: Fundamental and Applied Research Programme

Role of HHV-6-induced mitochondrial dysfunction in myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS)

Prusty, B. K. (Project leader)

1/01/22 → 31/01/25

Project: Projects outside RSU

Support for involving doctoral students in scientific research and studies

Bartuševiča, S. (Administrative manager), Sīle, L. (Expert (PhD student)), Lifšics, A. (Expert (PhD student)), Līcīte, B. (Expert (PhD student)), Zdanovskis, N. (Expert (PhD student)), Kiseļova, O. (Expert (PhD student)), Sokolovska, L. (Expert (PhD student)), Vinogradova, V. V. (Expert (PhD student)), Vizgunova-Vikmane, E. E. (Expert (PhD student)), Miļuna-Meldere, S. (Expert (PhD student)), Šneidere, K. (Expert (PhD student)), Semjonova, G. (Expert (PhD student)), Kigitoviča, D. (Expert (PhD student)), Kļaviņa-Makrecka, S. (Expert (PhD student)), Madelāne, M. (Expert (PhD student)), Šitovs, A. (Expert (PhD student)), Kļaviņa, A. (Expert (PhD student)), Balcere, A. (Expert (PhD student)), Vanaga, I. (Expert (PhD student)), Lakiša, S. (Expert (PhD student)), Grinciuns, M. (Expert (PhD student)), Mieze, K. (Expert (PhD student)), Berga-Švītiņa, E. (Expert (PhD student)), Leidere-Reine, A. (Expert (PhD student)), Dzudzilo, M. (Expert (PhD student)), Ozola, M. (Expert (PhD student)), Avena, L. (Expert (PhD student)), Brečs, I. (Expert (PhD student)), Kiščenko, D. (Expert (PhD student)), Krūmiņa, J. (Expert (PhD student)), Lucāne, Z. (Expert (PhD student)), Meidrops, K. (Expert (PhD student)), Kuļigina, N. (Expert (PhD student)), Savicka, L. (Expert (PhD student)), Savickis, V. (Expert (PhD student)), Šetlere, S. (Expert (PhD student)), Vargulis, M. (Expert (PhD student)) & Zariņš, K. (Expert (PhD student))

European Social Fund, Latvia State Budget funding

1/04/21 → 30/11/23

Project: EU Structural Funds › ESF

Improvement of Natural Glycopeptide Isolation Technology and Studying of Their Immune-Modulating Properties (Stage II)

Saulīte, V. (Project leader), Černobajeva, L. (Expert), Blumfelde-Rutka, K. (Expert), Zamerovska, D. (Administrative manager) & Gulbe, G. (Expert)

Investment and Development Agency of Latvia

1/12/20 → 30/06/22

Project: EU Structural Funds › ERDF

The role of human herpesvirus-6 infection and alcohol abuse in the development of neuroinflammation

Skuja, S. (Project leader), Strojeva, S. (Assistant (student)), Svirskis, Š. (Expert), Blūms, D. (Expert), Starta, G. (Participant), Garnizone, M. (Assistant (student)) & Jain, N. (Assistant (student))

Latvian Council of Science

1/12/20 → 31/12/21

Project: Fundamental and Applied Research Programme

Human herpesvirus 6 chemokine receptor mediated immunomodulating mechanism involvement in autoimmune thyroiditis development

Sultanova, A. (Project leader), Čistjakovs, M. (Expert), Sokolovska, L. (Expert (PhD student)) & Strojeva, S. (Expert)

Latvian Council of Science

1/12/20 → 31/12/21

Project: Fundamental and Applied Research Programme

Bacteriophage-derived dsRNA as a potential agent against coronavirus

Pjanova, D. (Project leader), Vaivode, K. (Expert), Verhovcova, I. (Expert) & Kreishmane, M. (Expert)

1/12/20 → 31/12/21

Project: Projects outside RSU

Pathogenicity of human Hepatitis C virus relying on enzymatic properties of viral RNA-dependent RNA-polymerase

Issagouliantis, M. (Project leader), Dudorova, A. (Assistant (student)) & Jansons, J. (Project leader)

Latvian Council of Science

1/12/20 → 31/12/21

Project: Fundamental and Applied Research Programme

VirA: Reducing networking gaps between Rīga Stradiņš University (RSU) and internationally - leading counterparts in viral infection-induced autoimmunity research

Murovska, M. (Project leader), Lunga, A. (Work package leader), Doniņa, S. (Work package leader), Nora-Krūkle, Z. (Work package leader), Groma, V. (Work package leader), Krūmiņa, A. (Work package leader), Rasa-Dzelzkalēja, S. (Work package leader), Holodņuka, I. (Participant), Skuja, S. (Leading expert) & Lejnieks, A. (Other)

European Commission

1/12/20 → 30/11/23

Project: EU Programmes › Horizon 2020

Role of viruses HHV-7 and EBV in the pathogenesis of oral lichen planus and aphthous stomatitis

Kakare, D. (Project leader), Cema, I. (Supervisor) & Murovska, M. (Supervisor)

1/10/20 → 30/09/24

Project: PhD projects

New biomarkers for diagnosis and prognosis of calcific aortic valve stenosis

Mackēvičs, V. (Project leader), Tretjakovs, P. (Participant), Gersone, G. (Participant), Cirse, M. (Participant), Bahs, G. (Participant), Platkājis, A. (Participant) & Svirskis, Š. (Participant)

Riga Stradins University

14/09/20 → 13/09/21

Project: RSU grants

Study of the DNA methylation degree/pattern of the PSA, PSMA and TCERG1L genes in prostate cancerous and non-cancerous cell lines

Bariševs, M. (Project leader), Sasoveca, I. (Participant) & Maksimova, I. (Participant)

Riga Stradins University

14/09/20 → 13/09/21

Project: RSU grants

Dynamics of serum cytokines in patients with pulmonary tuberculosis

Eglīte, J. (Project leader), Koļesova, O. (Participant), Ozere, I. (Participant) & Vīksna, A. (Participant)

Riga Stradins University

1/08/20 → 31/07/21

Project: RSU grants

Clinical, biochemical, immunogenetic paradigms of Covid-19 infection and their correlation with socio-demographic, etiological, pathogenetic, diagnostic, therapeutically and prognostically important factors to be included in guidelines

Vīksna, L. (Project leader), Leja, M. (Work package leader), Murovska, M. (Project leader), Gardovska, D. (Work package leader), Koļesova, O. (Leading expert), Laivacuma, S. (Leading expert), Platkājis, A. (Work package leader), Eglīte, J. (Work package leader), Šķesters, A. (Work package leader), Radziņa, M. (Expert), Stūre, G. (Expert), Zavadska, D. (Expert), Storoženko, J. (Expert), Rozentāle, B. (Expert), Zeltiņa, I. (Expert), Koļesovs, A. (Work package leader), Nora-Krūkle, Z. (Expert), Grāvelsiņa, S. (Expert), Karelis, G. (Expert), Sperga, M. (Expert), Plaudis, H. (Expert), Arāja, D. (Expert), Dzīvīte-Krišāne, I. (Expert), Aleksejeva, E. (Expert), Puķīte, I. (Expert), Grantiņa, I. (Expert), Ivanova, V. (Administrative manager), Ivanovs, A. (Expert (PhD student)), Arutjuņana, S. (Expert (PhD student)), Vanaga, I. (Expert (PhD student)), Kustovs, D. (Expert (PhD student)), Čistjakovs, M. (Expert (PhD student)), Strojeva, S. (Expert (PhD student)), Sokolovska, L. (Expert (PhD student)), Meiere, A. (Expert (PhD student)), Bajāre, L. (Expert (PhD student)) & Vilmane, A. (Expert (PhD student))

Latvian Council of Science

1/07/20 → 30/06/21

Project: National Research Programme

Establishment of COVID-19 related biobank and integrated platform for research data in Latvia

Klovins, J. (Project leader), Nora-Krūkle, Z. (Partner's coordinator), Vilne, B. (Leading expert), Rozentāle, B. (Leading expert), Vilmane, A. (Expert), Krūmiņa, A. (Leading expert), Terentjeva-Decuka, A. (Expert (PhD student)), Vecvagare, K. (Assistant (student)) & Vaidere, D. (Other)

Latvian Council of Science

1/07/20 → 31/03/21

Project: National Research Programme

Infectious triggers behind ME/CFS.

Prusty, B. K. (Project leader)

1/04/20 → 31/03/21

Project: Projects outside RSU

Improving Natural Glycopeptide Isolation Technology and Studying Their Immune-Modulating Properties (Stage I)

Saulīte, V. (Project leader)

Investment and Development Agency of Latvia

1/04/20 → 30/09/20

Project: EU Structural Funds › ERDF

Selection of biomarkers in ME/CFS for patient stratification and treatment surveillance / optimisation

Murovska, M. (Project leader), Berķis, U. (Leading expert), Krūmiņa, A. (Expert), Svirskis, Š. (Expert), Grāvelsiņa, S. (Expert (PhD student)), Arāja, D. (Expert (PhD student)), Vilmane, A. (Expert (PhD student)), Vecvagare, K. (Expert (PhD student)), Maksimova, I. (Participant) & Vārna, V. (Participant)

Latvian Council of Science

1/01/20 → 30/06/23

Project: Fundamental and Applied Research Programme

EATRIS-Plus: Consolidating the capacities of EATRIS-ERIC for Personalised Medicine

Andreu, T. (Project leader), Nora-Krūkle, Z. (Partner's coordinator), Rasa-Dzelzkalēja, S. (Leading expert) & Krūmiņa, J. (Work package leader)

European Commission

1/01/20 → 31/12/23

Project: EU Programmes › Horizon 2020

Differences in biochemical and immunogenetic markers of apoptosis and fibrosis and endotoxins in patients with immunosuppressive RNA virus (HIV, HCV)-induced chronic infections and their correlation to infection severity

Vīksna, L. (Project leader), Krūmiņa, A. (Expert), Eglīte, J. (Expert) & Koļesova, O. (Expert)

Riga Stradins University

2/09/19 → 31/03/20

Project: RSU grants

Study of the effect of Oct4 DNA methylation degree/methylation patterns and the level of Oct4 isoforms expression on identification of the prostate cancer aggressiveness

Bariševs, M. (Project leader)

Riga Stradins University

1/05/19 → 31/03/20

Project: RSU grants

Involvement of Persistent Viral Infections in Modulation of Immune System and Development of Autoimmune Diseases

Murovska, M. (Project leader)

Riga Stradins University

1/05/19 → 31/03/20

Project: RSU grants

Study of Fullerene Nanoparticles as Adjuvants/Carriers for Vaccine Development

Sultanova, A. (Project leader), Čistjakovs, M. (Expert (PhD student)), Cunskis, E. (Expert), Sokolovska, L. (Assistant (student)) & Strojeva, S. (Assistant (student))

Riga Stradins University

1/05/19 → 31/03/20

Project: RSU grants

HLA Class II alleles, levels of cytokines, and expression level of ORAI1 and STIM1 genes in blood as predictors of sputum culture conversion status in patients with different forms of tuberculosis

Eglīte, J. (Project leader), Koļesova, O. (Leading expert) & Kramiča, K. (Participant)

Riga Stradins University

1/04/19 → 31/03/20

Project: RSU grants

Understanding the biology of the minimal residual disease after targeted therapy of BRAF mutant melanoma

Pjanova, D. (Project leader) & Kreishmane, M. (Expert)

1/03/19 → 28/02/22

Project: Projects outside RSU

Institute of Microbiology and Virology

Projects

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