Projects per year
Organisation profile
Organisation profile
A relatively small but well-shaped group under the scientific direction of Dr. Valentyn Mohylyuk consists of pharmaceutical and chemical scientists, specialists, and one engineer.
Long-term objectives
The long-term objective is to become a world-class research group and intellectual attraction site for academic and industrial collaboration. Thus, we are developing specific directions and facilities to build expertise in pharmaceutical formulation, drug delivery and respective analytical methods.
Research directions
Among the research directions, we are highlighting the following:
· improving the solubility and bioavailability (BA) of poorly soluble drugs of oral dosage forms (ODF),
· optimization of the pharmacokinetics (PK) and custom properties of ODF,
· development of “special” ODF, incl. abuse-deterrent formulation,
· continuous manufacturing stages of solid DF,
· 3D printing and long-acting implants,
· extraction and analytical characterization.
Research techniques
We exploit solid-state characterization, compaction simulation, vacuum-compression-moulding sample preparation, mechanical, particle size distribution, molten materials and liquids rheology, powder and solid dosage form pharmaco-technological characterization, spectroscopic, and chromatographic methods to support our research activities.
Rotor-evaporation, air-jet micronization, high-shear and fluid-bed processing, hot-melt extrusion, vacuum-compression-moulding, roll-compaction, compaction simulation, tableting, fluid-bed and pan coating, capsule-filling, packaging, etc. are part of our technological toolkit.
Group activities
· the development of pharmaceutical technologies and analytical methods, incl. increasing the technology readiness level (TRL),
· close collaboration with international pharmaceutical companies, incl. development of products, technologies, and applications,
· application and performance of scientific projects (national and international level),
· scientific participation in the leading pharmaceutical events (focusing on the group's sci scope),
· supervising PhD and MS students' scientific works,
· collaboration with local and foreign academic institutions, incl. Erasmus programs.
We are open to cooperation
· in the above or related directions,
· in co-application/participation in founded scientific projects,
· build a reputation by publishing in reputable peer-reviewed journals,
· co-participating in prestigious international pharmaceutical events.
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Collaborations and top research areas from the last five years
Profiles
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The revision of oral products with herbal extracts in order to find the possibility to improve their bioavailability
Žogota, M. (Project leader), Mohylyuk, V. (Supervisor) & Šitovs, A. (Supervisor)
1/10/24 → 29/09/28
Project: PhD projects
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Abuse-Deterrent Formulation
Frolova, A. J. (Participant), Kukuls, K. (Expert), Nikolajeva, I. (Leading expert) & Mohylyuk, V. (Supervisor)
11/07/24 → 11/12/25
Project: Student projects
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Suitability of sugar alcohols (polyols) as binders in twin-screw melt granulation for preparation of high-drug-loaded immediate-release tablets with superior mechanical properties
Mohylyuk, V. (Project leader), Buczkowska, E. M. (Leading expert), Horvath, Z. M. (Expert), Kukuls, K. (Expert) & Frolova, A. J. (Expert)
1/04/24 → 31/03/26
Project: Consolidation grants
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Dissolution-Permeation Systems in Biopharmaceutical Research: A Graphical Review on the Current State-of-the-Art
Šitovs, A., Cernisova, V. & Mohylyuk, V. (Corresponding Author), May 2025, In: Journal of Drug Delivery Science and Technology. 107, 106814.Research output: Contribution to journal › Review article › peer-review
Open AccessFile1 Downloads (Pure) -
Effect of Magnesium Stearate Lubrication on the Tableting of Spray-dried Grades of Mannitol and Fluid-Bed Granulated Grade of Isomalt
Mohylyuk, V. (Corresponding Author), Kukuls, K., Frolova, A. J., Horvath, Z. M., Buczkowska, E. M. & Pētersone, L., 24 Mar 2025, p. M034 .Research output: Contribution to conference › Poster
Open AccessFile1 Downloads (Pure) -
Effect of Microcrystalline Cellulose (MCC) Grade on the Properties of Twin-Screw Melt Granulated Formulations of Ascorbic Acid
Mohylyuk, V., Ding, Y., Shmyrova, J. & Andrews, G. P., 24 Mar 2025, p. M095.Research output: Contribution to conference › Poster
Open AccessFile1 Downloads (Pure)
Datasets
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Intrinsic Dissolution Rate (IDR) of Polyols
Gniazdowska, E. M. (Creator), Frolova, A. J. (Creator), Kukuls, K. (Creator), Horvath, Z. M. (Creator) & Mohylyuk, V. (Creator), Riga Stradins University, 6 Feb 2025
DOI: 10.48510/FK2/BJPEC8, https://dataverse.rsu.lv/dataset.xhtml?persistentId=doi:10.48510/FK2/BJPEC8
Dataset
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Loss on Drying (LoD) of Polyols
Frolova, A. J. (Creator), Kukuls, K. (Creator), Horvath, Z. M. (Creator), Gniazdowska, E. M. (Creator) & Mohylyuk, V. (Creator), Riga Stradins University, 21 Jan 2025
DOI: 10.48510/FK2/XILW3Z, https://dataverse.rsu.lv/dataset.xhtml?persistentId=doi:10.48510/FK2/XILW3Z
Dataset
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Optical Microscopy of Polyols
Kukuls, K. (Creator), Frolova, A. J. (Creator), Horvath, Z. M. (Creator), Gniazdowska, E. M. (Creator) & Mohylyuk, V. (Creator), Riga Stradins University, 22 Jan 2025
DOI: 10.48510/FK2/RBPONG, https://dataverse.rsu.lv/dataset.xhtml?persistentId=doi:10.48510/FK2/RBPONG
Dataset
Prizes
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Letter of Appreciation from the President of the Latvian Academy of Sciences
Bandere, D. (Recipient), Koka, R. (Recipient), Brangule, A. (Recipient), Bārzdiņa, A. (Recipient), Lauberte, L. (Recipient), Mohylyuk, V. (Recipient), Radziņš, O. (Recipient), Teterovska, R. (Recipient), Brante, O. (Recipient), Paulausks, A. (Recipient), Kovalcuka, L. (Recipient), Keidāne, D. (Recipient), Kļaviņa, A. (Recipient) & Ganola, K. (Recipient), Feb 2024
Prize: Honorary award
Activities
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Thermal post-processing of HME-pellets: smoothed taste-masked matrix pellets
Kaufelde, P. (Co-author), Aņiskevičs, A. (Co-author), Sevcenko, J. (Co-author), Žogota, M. (Co-author) & Mohylyuk, V. (Speaker)
2 Jul 2025 → 4 Jul 2025Activity: Talk or presentation types › Oral presentation
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Marcin Skotinicki
Mohylyuk, V. (Host)
7 Apr 2025 → 11 Apr 2025Activity: Hosting a visitor types › Hosting an academic visitor
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Oliwia Kordyl
Mohylyuk, V. (Host)
1 Apr 2025 → 11 Apr 2025Activity: Hosting a visitor types › Hosting an academic visitor
Press/Media
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News > FDM 3D-printed oral dosage form of prednisolone – Improvement of printability and influencing drug release
Horvath, Z. M., Grundsteins , K., Radziņš, O., Kons, A., Bērziņš, A., Viter, R., Lamprou, D. A. & Mohylyuk, V.
5/03/25
1 item of Media coverage
Press/Media
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NEWS> High drug-loaded amorphous solid dispersions of a poor glass forming drug: The impact of polymer type and cooling rate on amorphous drug behaviour
Kolisnyk, T., Mohylyuk, V. & Andrews, G. P.
23/12/24
1 item of Media coverage
Press/Media
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News > Ex vivo permeability study of poorly soluble drugs across gastrointestinal membranes: acceptor compartment media composition
1/12/24
1 item of Media coverage
Press/Media