Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
3.1 Basic medicine, Doctor of Philosophy (PhD), A microcell hybrid based Elimination Test to identify human chromosome 3 regions that antagonize tumor growth, Karolinska Institutet
1 Mar 1997 → 10 Jun 2003
Award Date: 10 Jun 2003
1.6 Biological sciences, Doctor of Science, Augsti jūtīgas hepatīta B vīrusa virsmas antigēna neteikšanas metodes izmantojot poliklonālās, monoklonālās un antiidiotipiskās antivielas, University of Latvia
Award Date: 19 Jan 2001
1.6 Biological sciences, Doctor of Science, High-sensitive methods of detection of the hepatitis B surface antigen using polyclonal, monoclonal, and anti-idiotype antibodies, August Kirchenstein Institute of Microbiology and Virology
10 Jun 1980 → 20 Dec 1988
Award Date: 20 Dec 1988
1.6 Biological sciences, Master of Science, Hepatitis B virus, University of Latvia
1 Sept 1975 → 10 Jun 1980
Award Date: 10 Jun 1980
3.1 Basic medicine, Expert, Latvian Council of Science
3 Nov 2022 → 2 Nov 2025
3.1 Basic medicine, Expert, Latvian Council of Science
19 Dec 2019 → 18 Dec 2022
1.6 Biological sciences, Expert, Latvian Council of Science
26 Nov 2016 → 25 Nov 2019
External positions
Leading Researcher, Riga Stradins University
1 Sept 2008 → 31 Dec 2017
Researcher, Karolinska Institutet
1 Sept 2006 → 31 Aug 2008
Researcher, post-doctoral, Uppsala University
1 Sept 2004 → 31 Aug 2006
Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
1 Jul 2003 → 31 Dec 2004
Ph.D. Student, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
1 Mar 1997 → 10 Jun 2003
Guest-Researcher, Karolinska Institutet
1 Mar 1992 → 28 Feb 1997
Researcher, August Kirchenstein Institute of Microbiology and Virology
1 Jul 1980 → 28 Feb 1992
Field of Science
- 3.1 Basic medicine
- 1.6 Biological sciences
Keywords
- Cancer cell molecular biology
- B-cell hematological malignancy
- Virology: EBV, HHV-6
- Epigenetics and functional genomics of cancer cell
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 10 Finished
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Assessment of new biomarkers for the prognosis and treatment prediction in chronic lymphocytic leukemia
Holodņuka, I. (Project leader) & Pavlova, J. (Expert)
1/04/22 → 31/03/23
Project: RSU grants
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VirA: Reducing networking gaps between Rīga Stradiņš University (RSU) and internationally - leading counterparts in viral infection-induced autoimmunity research
Murovska, M. (Project leader), Lunga, A. (Work package leader), Doniņa, S. (Work package leader), Nora-Krūkle, Z. (Work package leader), Groma, V. (Work package leader), Krūmiņa, A. (Work package leader), Rasa-Dzelzkalēja, S. (Work package leader), Holodņuka, I. (Participant), Skuja, S. (Leading expert) & Lejnieks, A. (Other)
1/12/20 → 30/11/23
Project: EU Programmes › Horizon 2020
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Investigation of the chemokine receptors CCR1 and CCR2 and EBV infection aimed on disclosure of new markers that can predict the high risk for progression of chronic lymphocytic leukemia
Holodņuka, I. (Project leader), Kozireva, S. (Participant), Zvejniece, L. (Expert (PhD student)), Pavlova, J. (Participant) & Demida, O. (Assistant (student))
31/08/18 → 30/11/21
Project: Fundamental and Applied Research Programme
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VACTRAIN: Twinning on DNA-Based Cancer Vaccines
Lunga, A. (Administrative manager), Issagouliantis, M. (Project leader) & Holodņuka, I. (Participant)
1/01/16 → 31/12/18
Project: EU Programmes › Horizon 2020
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Investigation of chemokine receptors CCR1 and CCR2 as potential diagnostic markers of B-cell malignancy progression
Holodņuka, I. (Work package leader), Kozireva, S. (Project leader), Bariševs, M. (Expert), Sultanova, A. (Expert), Čistjakovs, M. (Expert) & Lejniece, S. (Work package leader)
1/01/14 → 31/12/17
Project: Fundamental and Applied Research Programme
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Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2
Zvejniece, L., Kozireva, S., Rudevica, Z., Leonciks, A., Ehlin-Henriksson, B., Kashuba, E. & Kholodnyuk, I. (Corresponding Author), 22 Mar 2022, In: International Journal of Molecular Sciences. 23, 7, 3434.Research output: Contribution to journal › Article › peer-review
Open Access3 Citations (Scopus) -
Delivery of oligonucleotide-based therapeutics: challenges and opportunities
Hammond, S. M., Aartsma-Rus, A., Alves, S., Borgos, S. E., Buijsen, R. A. M., Collin, R. W. J., Covello, G., Denti, M. A., Desviat, L. R., Echevarría, L., Foged, C., Gaina, G., Garanto, A., Goyenvalle, A. T., Guzowska, M., Holodnuka, I., Jones, D. R., Krause, S., Lehto, T. & Montolio, M. & 2 others, , 9 Apr 2021, In: EMBO Molecular Medicine. 13, 4, e13243.Research output: Contribution to journal › Review article › peer-review
Open AccessFile202 Citations (Scopus)46 Downloads (Pure) -
Chemokine Receptors CCR1 and CCR2 on Peripheral Blood Mononuclear Cells of Newly Diagnosed Patients with the CD38-Positive Chronic Lymphocytic Leukemia
Kholodnyuk, I. (Corresponding Author), Rivkina, A., Hippe, L., Svirskis, S., Kozireva, S., Ventina, I., Spaka, I., Soloveichika, M., Pavlova, J., Murovska, M. & Lejniece, S., Jul 2020, In: Journal of clinical medicine. 9, 7, p. 1-17 17 p., 2312.Research output: Contribution to journal › Article › peer-review
Open Access2 Citations (Scopus) -
Positioning Europe for the EPITRANSCRIPTOMICS challenge
Jantsch, M. F., Quattrone, A., O'Connell, M., Helm, M., Frye, M., Macias-Gonzales, M., Ohman, M., Ameres, S., Willems, L., Fuks, F., Oulas, A., Vanacova, S., Nielsen, H., Bousquet-Antonelli, C., Motorin, Y., Roignant, J. Y., Balatsos, N., Dinnyes, A., Baranov, P. & Kelly, V. & 40 others, , 3 Jun 2018, In: RNA Biology. 15, 6, p. 829-831 3 p.Research output: Contribution to journal › Comment/debate
Open AccessFile18 Citations (Scopus)11 Downloads (Pure) -
Proportion of the CD19-positive and CD19-negative lymphocytes and monocytes within the peripheral blood mononuclear cell set is characteristic for rheumatoid arthritis
Kholodnyuk, I., Kadisa, A., Svirskis, S., Gravelsina, S., Studers, P., Spaka, I., Sultanova, A., Lejniece, S., Lejnieks, A. & Murovska, M., Oct 2019, In: Medicina (Lithuania). 55, 10, 14 p., 630.Research output: Contribution to journal › Article › peer-review
Open AccessFile10 Citations (Scopus)12 Downloads (Pure)
Activities
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EBV Infection Promotes Migration of The Host B Cells Via Up-Regulation of The Inflammatory Chemokine Receptors CCR1 and CCR2
Holodņuka, I. (Speaker)
15 Jun 2023Activity: Talk or presentation types › Oral presentation
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RSU International Research Conference 2023: Knowledge for Use in Practice
Nora-Krūkle, Z. (Scientific committee member), Vīksna, L. (Scientific committee member), Kroiča, J. (Scientific committee member), Zavadska, D. (Scientific committee member), Kadiša, A. (Scientific committee member), Kurjāne, N. (Scientific committee member), Skadiņš, I. (Scientific committee member), Pētersons, A. (Scientific committee member), Ķēniņa, V. (Scientific committee member), Schneider, M. (Scientific committee member), Gilburd, B. (Scientific committee member), Murovska, M. (Scientific committee member), Sultanova, A. (Scientific committee member), Holodņuka, I. (Scientific committee member), Rasa-Dzelzkalēja, S. (Scientific committee member), Koļesova, O. (Scientific committee member) & Svirskis, Š. (Scientific committee member)
29 Mar 2023 → 31 Mar 2031Activity: Participating in or organising an event types › Organising a conference, workshop, ...
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Proportions of the Peripheral Blood Mononuclear Cells in Patients with Rheumatoid Arthritis
Holodņuka, I. (Speaker)
28 Oct 2021Activity: Talk or presentation types › Oral presentation
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MDPI Multidisciplinary Digital Publishing Institute (Publisher)
Holodņuka, I. (Reviewer of journal article)
16 Feb 2023 → 10 Mar 2023Activity: Publication peer-review and editorial work types › Publication Peer-review
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MDPI Multidisciplinary Digital Publishing Institute (Publisher)
Holodņuka, I. (Reviewer of journal article)
18 Nov 2022Activity: Publication peer-review and editorial work types › Publication Peer-review