Projects per year
Personal profile
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
3.1 Basic medicine, Doctor of Philosophy (PhD), A microcell hybrid based Elimination Test to identify human chromosome 3 regions that antagonize tumor growth, Karolinska Institutet
1 Mar 1997 → 10 Jun 2003
Award Date: 10 Jun 2003
1.6 Biological sciences, Doctor of Science, Augsti jūtīgas hepatīta B vīrusa virsmas antigēna neteikšanas metodes izmantojot poliklonālās, monoklonālās un antiidiotipiskās antivielas, University of Latvia
Award Date: 19 Jan 2001
1.6 Biological sciences, Doctor of Science, High-sensitive methods of detection of the hepatitis B surface antigen using polyclonal, monoclonal, and anti-idiotype antibodies, August Kirchenstein Institute of Microbiology and Virology
10 Jun 1980 → 20 Dec 1988
Award Date: 20 Dec 1988
1.6 Biological sciences, Master of Science, Hepatitis B virus, University of Latvia
1 Sept 1975 → 10 Jun 1980
Award Date: 10 Jun 1980
3.1 Basic medicine, Expert, Latvian Council of Science
3 Nov 2022 → 2 Nov 2025
3.1 Basic medicine, Expert, Latvian Council of Science
19 Dec 2019 → 18 Dec 2022
1.6 Biological sciences, Expert, Latvian Council of Science
26 Nov 2016 → 25 Nov 2019
External positions
Leading Researcher, Riga Stradins University
1 Sept 2008 → 31 Dec 2017
Researcher, Karolinska Institutet
1 Sept 2006 → 31 Aug 2008
Researcher, post-doctoral, Department of Development and Genetics, Evolutionary Biology Centre (EBC), Uppsala University
1 Sept 2004 → 31 Aug 2006
Researcher, Department of Microbiology, Tumor and Cell Biology, Karolinska Institute
1 Jul 2003 → 31 Dec 2004
Ph.D. Student, Microbiology and Tumor Biology Center (MTC), Karolinska Institute
1 Mar 1997 → 10 Jun 2003
Guest-Researcher, Karolinska Institutet
1 Mar 1992 → 28 Feb 1997
Researcher, August Kirchenstein Institute of Microbiology and Virology
1 Jul 1980 → 28 Feb 1992
Field of Science
- 3.1 Basic medicine
Keywords
- Cancer cell molecular biology
- B-cell hematological malignancy
- Virology: EBV, HHV-6
- Epigenetics and functional genomics of cancer cell
Fingerprint
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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VirA: Reducing networking gaps between Rīga Stradiņš University (RSU) and internationally - leading counterparts in viral infection-induced autoimmunity research
Murovska, M., Lunga, A., Doniņa, S., Nora-Krūkle, Z., Groma, V., Krūmiņa, A., Rasa-Dzelzkalēja, S., Holodņuka, I. & Skuja, S.
1/12/20 → 30/11/23
Project: EU Programmes › Horizon 2020
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Assessment of new biomarkers for the prognosis and treatment prediction in chronic lymphocytic leukemia
1/04/22 → 31/03/23
Project: RSU grants
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Investigation of the chemokine receptors CCR1 and CCR2 and EBV infection aimed on disclosure of new markers that can predict the high risk for progression of chronic lymphocytic leukemia
Holodņuka, I., Kozireva, S., Zvejniece, L., Pavlova, J. & Demida, O.
31/08/18 → 30/11/21
Project: Fundamental and Applied Research Programme
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VACTRAIN: Twinning on DNA-Based Cancer Vaccines
Lunga, A., Issagouliantis, M. & Holodņuka, I.
1/01/16 → 31/12/18
Project: EU Programmes › Horizon 2020
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Investigation of chemokine receptors CCR1 and CCR2 as potential diagnostic markers of B-cell malignancy progression
Holodņuka, I., Kozireva, S., Bariševs, M., Sultanova, A., Čistjakovs, M. & Lejniece, S.
1/01/14 → 31/12/17
Project: Fundamental and Applied Research Programme
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Expression of the Chemokine Receptor CCR1 in Burkitt Lymphoma Cell Lines Is Linked to the CD10-Negative Cell Phenotype and Co-Expression of the EBV Latent Genes EBNA2, LMP1, and LMP2
Zvejniece, L., Kozireva, S., Rudevica, Z., Leonciks, A., Ehlin-Henriksson, B., Kashuba, E. & Kholodnyuk, I., 22 Mar 2022, In: International Journal of Molecular Sciences. 23, 7, 3434.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Analysis of the chemokine receptor CCR1 mutations in patients with chronic lymphocytic leukemia
Zvejniece, L., Rivkina, A., Kurbatska, V., Kistkins, S., Pavlova, J., Leončiks, A., Lejniece, S. & Holodņuka, I., 24 Mar 2021, p. 118.Research output: Contribution to conference › Abstract › peer-review
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CHEMOKINE RECEPTORS CCR1 AND CCR2 ARE UP-REGULATED ON CIRCULATING LEUKEMIC CELLS OF THE UNTREATED CD38+ CLL PATIENTS WITH THE HIGH EBV DNA-COPY LOAD
Kholodnyuk, I., Hippe, L., Rivkina, A., Svirskis, S., Sultanova, A., Kozireva, S., Pavlova, J., Murovska, M. & Lejniece, S., 15 Sept 2021, p. 210. 1 p.Research output: Contribution to conference › Abstract › peer-review
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Delivery of oligonucleotide-based therapeutics: challenges and opportunities
Hammond, S. M., Aartsma-Rus, A., Alves, S., Borgos, S. E., Buijsen, R. A. M., Collin, R. W. J., Covello, G., Denti, M. A., Desviat, L. R., Echevarría, L., Foged, C., Gaina, G., Garanto, A., Goyenvalle, A. T., Guzowska, M., Holodnuka, I., Jones, D. R., Krause, S., Lehto, T., Montolio, M., & 2 others, 9 Apr 2021, In: EMBO Molecular Medicine. 13, 4, e13243.Research output: Contribution to journal › Review article › peer-review
Open AccessFile136 Citations (Scopus)23 Downloads (Pure) -
EPSTEIN BARR VIRUS INFECTION IN NEWLY DIAGNOSED CD38-POSITIVE AND CD38-NEGATIVE PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA
Kozireva, S., Zvejniece, L., Rivkina, A., Pavlova, J., Murovska, M., Lejniece, S. & Kholodnyuk, I., 15 Sept 2021, p. 218. 1 p.Research output: Contribution to conference › Abstract › peer-review
Activities
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RSU International Research Conference 2023: Knowledge for Use in Practice
Zaiga Nora-Krūkle (Scientific committee member), Ludmila Vīksna (Scientific committee member), Juta Kroiča (Scientific committee member), Dace Zavadska (Scientific committee member), Anda Kadiša (Scientific committee member), Nataļja Kurjāne (Scientific committee member), Ingus Skadiņš (Scientific committee member), Aivars Pētersons (Scientific committee member), Viktorija Ķēniņa (Scientific committee member), Marion Schneider (Scientific committee member), Boriss Gilburd (Scientific committee member), Modra Murovska (Scientific committee member), Alīna Sultanova (Scientific committee member), Irina Holodņuka (Scientific committee member), Santa Rasa-Dzelzkalēja (Scientific committee member), Oksana Koļesova (Scientific committee member) & Šimons Svirskis (Scientific committee member)
29 Mar 2023 → 31 Mar 2031Activity: Participating in or organising an event types › Organising a conference, workshop, ...
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MDPI Multidisciplinary Digital Publishing Institute (Publisher)
Irina Holodņuka (Reviewer of journal article)
18 Nov 2022Activity: Publication peer-review and editorial work types › Publication Peer-review
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International Journal of Molecular Sciences (Journal)
Irina Holodņuka (Reviewer of journal article)
5 Oct 2022 → 13 Oct 2022Activity: Publication peer-review and editorial work types › Publication Peer-review
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Biomedicines (Journal)
Irina Holodņuka (Reviewer of journal article)
14 Feb 2022 → 27 Feb 2022Activity: Publication peer-review and editorial work types › Publication Peer-review
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Viruses (Journal)
Irina Holodņuka (Reviewer of journal article)
16 Nov 2021 → 5 Jan 2022Activity: Publication peer-review and editorial work types › Publication Peer-review